Actively Recruiting

Phase Not Applicable
Age: 25Years - 70Years
All Genders
Healthy Volunteers
NCT05907161

Low Laser Therapy and Hyaluronic Acid as an Adjunct to Non-surgical Periodontal Therapy

Led by University of Ljubljana · Updated on 2025-09-19

45

Participants Needed

1

Research Sites

138 weeks

Total Duration

On this page

Sponsors

U

University of Ljubljana

Lead Sponsor

U

University Medical Centre Ljubljana

Collaborating Sponsor

AI-Summary

What this Trial Is About

Periodontal disease is an oral disease characterized by microbially associated, host-mediated inflammation of the periodontium. In the treatment of periodontal disease, conventional periodontal therapy includes both surgical and non-surgical approaches. Non-surgical therapy (i.e. scaling and root planing - SRP) remains an essential part of periodontal therapy. Here, diseased root surface debridement utilizing different hand and ultrasonic instrumentation is performed to facilitate periodontal re-attachment and to reduce the bacterial mass in the periodontal pocket. In the last decade, the use of lasers (light amplification by stimulated emission of radiation) has occupied part of the dialogue within periodontology due to several proposed advantages. In the arena of periodontology, laser use, as an adjunct to non-surgical therapy, was demonstrated to enhance periodontal healing; however, it is still the matter of debate. Among laser applications, low-level laser therapy is recommended for its pain-reducing, woundhealing and anti-inflammatory effects. Hyaluronic acid is a non-sulfated glycosaminoglycan and a major component of the extracellular matrix. It is found in various body fluids, such as gingival crevicular fluid, saliva, serum and synovial fluid. Anti-inflammatory, anti-edematous and anti-bacterial activities of hyaluronic acid have been investigated in dentistry, specially in periodontology.

CONDITIONS

Official Title

Low Laser Therapy and Hyaluronic Acid as an Adjunct to Non-surgical Periodontal Therapy

Who Can Participate

Age: 25Years - 70Years
All Genders
Healthy Volunteers

Eligibility Criteria

Eligible

You may qualify if you...

  • Systemically healthy
  • Non-smokers
  • Untreated periodontal disease (stage 3, grade B or C)
  • Plaque index not exceeding 20%
  • Having at least 20 teeth in the mouth
Not Eligible

You will not qualify if you...

  • Having systemic diseases affecting periodontal health
  • Taking medications that affect periodontal health
  • Smokers
  • Pregnant or lactating women
  • Antibiotic treatment within the last 12 months
  • Periodontal treatment within the last year

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

Univerity Medical Center Ljubljana

Ljubljana, Slovenia, 1000

Actively Recruiting

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Research Team

E

Eva Skaleric, Dr.

CONTACT

A

Aleš Fidler, Dr.

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

DOUBLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

3

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Low Laser Therapy and Hyaluronic Acid as an Adjunct to Non-surgical Periodontal Therapy | DecenTrialz