Actively Recruiting
Low Laser Therapy and Hyaluronic Acid as an Adjunct to Non-surgical Periodontal Therapy
Led by University of Ljubljana · Updated on 2025-09-19
45
Participants Needed
1
Research Sites
138 weeks
Total Duration
On this page
Sponsors
U
University of Ljubljana
Lead Sponsor
U
University Medical Centre Ljubljana
Collaborating Sponsor
AI-Summary
What this Trial Is About
Periodontal disease is an oral disease characterized by microbially associated, host-mediated inflammation of the periodontium. In the treatment of periodontal disease, conventional periodontal therapy includes both surgical and non-surgical approaches. Non-surgical therapy (i.e. scaling and root planing - SRP) remains an essential part of periodontal therapy. Here, diseased root surface debridement utilizing different hand and ultrasonic instrumentation is performed to facilitate periodontal re-attachment and to reduce the bacterial mass in the periodontal pocket. In the last decade, the use of lasers (light amplification by stimulated emission of radiation) has occupied part of the dialogue within periodontology due to several proposed advantages. In the arena of periodontology, laser use, as an adjunct to non-surgical therapy, was demonstrated to enhance periodontal healing; however, it is still the matter of debate. Among laser applications, low-level laser therapy is recommended for its pain-reducing, woundhealing and anti-inflammatory effects. Hyaluronic acid is a non-sulfated glycosaminoglycan and a major component of the extracellular matrix. It is found in various body fluids, such as gingival crevicular fluid, saliva, serum and synovial fluid. Anti-inflammatory, anti-edematous and anti-bacterial activities of hyaluronic acid have been investigated in dentistry, specially in periodontology.
CONDITIONS
Official Title
Low Laser Therapy and Hyaluronic Acid as an Adjunct to Non-surgical Periodontal Therapy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Systemically healthy
- Non-smokers
- Untreated periodontal disease (stage 3, grade B or C)
- Plaque index not exceeding 20%
- Having at least 20 teeth in the mouth
You will not qualify if you...
- Having systemic diseases affecting periodontal health
- Taking medications that affect periodontal health
- Smokers
- Pregnant or lactating women
- Antibiotic treatment within the last 12 months
- Periodontal treatment within the last year
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Univerity Medical Center Ljubljana
Ljubljana, Slovenia, 1000
Actively Recruiting
Research Team
E
Eva Skaleric, Dr.
CONTACT
A
Aleš Fidler, Dr.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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