Evaluating Low-Load Blood Flow Restriction Exercise for Pain Relief in Military Personnel with Lower Limb Injuries During Rehabilitation
Led by Defence Medical Rehabilitation Centre, UK · Updated on 2025-04-23
28
Participants Needed
1
Research Sites
4 weeks
Total Duration
AI-Summary
What this Trial Is About
Pain following musculoskeletal injury can limit recovery and reduce the number of military personnel fit for operations. This research aims to evaluate low load blood flow restriction BFR exercise as a method to reduce pain and improve rehabilitation outcomes in UK military patients with lower limb injuries. The study seeks to find the most effective BFR exercise protocol and understand the physiological reasons behind any pain relief it may provide.
Participants will receive one of two BFR exercise protocols using a pneumatic tourniquet system placed on the thigh during lower limb strengthening exercises such as leg press and knee extensor exercises. One group will have the cuff inflated to 80% of limb occlusion pressure, and the other to 40%. Both protocols involve four sets of specific repetitions at 20% of one repetition maximum. These interventions are combined with standard residential rehabilitation including group and individual exercise therapy, education sessions, and one-on-one support from various healthcare professionals.
During the study, participants will be assessed using various pain and function measurements before, during, and after the intervention, including the Brief Pain Inventory and Pressure Pain Threshold Testing. Other evaluations include strength tests, disability scores, wellbeing questionnaires, and pain ratings tracked daily. This detailed monitoring will help researchers measure pain changes, physical improvements, and the safety of BFR exercise. Participation lasts through the intervention and follow-up assessments over several days.
CONDITIONS
Brief Title
Is Low-load Resistance Training With Blood Flow Restriction Feasible During Rehabilitation of Military Personnel With Lower Limb Injuries? Phase One RCT.
Research Team
P
Peter Ladlow, PhD
L
Luke Hughes, PhD
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Unilateral lower limb injury where pain is the main factor limiting progress
Reduced occupational employability and function
Scheduled to attend a 3 week residential rehabilitation course at DMRC Stanford Hall
You will not qualify if you...
Any medical contraindication related to blood flow restriction
Non-musculoskeletal or serious pathological conditions such as inflammatory arthropathy, infection, or tumour
Spinal or referred pain from non-local sources
Physical impairments or co-morbidities preventing safe rehabilitation participation
Corticosteroid or analgesic injection to the affected area within the previous 7 days
Currently pregnant or not completed return to work assessment after childbirth
History of cardiovascular diseases like hypertension, thrombosis, or myocardial infarction
History of musculoskeletal disorders such as rheumatoid arthritis or severe osteoarthritis
History of neurological disorders including Alzheimer's disease or Parkinson's disease
Varicose veins in the lower limb
Acute viral or bacterial respiratory infection at screening
Known or suspected chronic exertional compartment syndrome in lower limb
Surgical metal components at cuff inflation site
History of diabetes, active cancer, or other listed serious conditions
History of unexplained fainting or dizziness during exercise
Increased risk of haemorrhagic stroke or exercise-induced rhabdomyolysis
Currently pregnant or related conditions preventing participation
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Implementation
Duration - 5 days
Participants receive low load blood flow restriction training using a pneumatic tourniquet system on the proximal thigh during lower limb strengthening exercises, combined with standard residential rehabilitation including exercise-based therapy, patient education, and one-on-one support sessions.
Daily visits for 5 days (in-person)
Follow-up
Duration - 3 days
Participants are assessed for recovery and outcomes after the intervention period.
1 follow-up visit (in-person) on day 8
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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Published Research Related To This Trial
Efficacy and acceptability of different blood flow restriction training interventions during the rehabilitation of military personnel with lower limb musculoskeletal injuries: protocol for a two-phase randomised controlled trial.
Luke Gray, Russ J Coppack, Robert Barker-Davies...