Actively Recruiting
Low Oxygen Therapy to Enhance Walking Recovery After SCI.
Led by Spaulding Rehabilitation Hospital · Updated on 2026-03-20
60
Participants Needed
2
Research Sites
173 weeks
Total Duration
On this page
Sponsors
S
Spaulding Rehabilitation Hospital
Lead Sponsor
U
United States Department of Defense
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this study is to determine how combining bouts of low oxygen, transcutaneous spinal cord stimulation, and walking training may improve walking function for people with chronic spinal cord injury of different age groups.
CONDITIONS
Official Title
Low Oxygen Therapy to Enhance Walking Recovery After SCI.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 18 to 80 years of age
- Medically stable with clearance from study physician
- Spinal cord injury at or below C1 and at or above L2 with some sensory or motor function preserved below the injury
- Non-progressive spinal injury
- ASIA scores of C-D at initial screening
- Able to complete 10-meter walk test without support
- Chronic injury more than 12 months post-injury
You will not qualify if you...
- Severe illness or pain including unhealed wounds, severe neuropathic or chronic pain, severe infections, hypertension, cardiovascular or pulmonary disease, severe osteoporosis, active heterotopic ossification, or systemic inflammation
- Mini-Mental Exam score less than 24
- Severe recurrent autonomic dysreflexia
- History of severe cardiovascular or pulmonary complications including hypertension with systolic blood pressure over 150 mmHg
- Pregnancy
- Botulinum toxin injections in lower extremity muscles within prior 3 months
- History of tendon or nerve transfer surgery in lower extremities
- Untreated severe sleep-disordered breathing with uncontrolled hypoxia
- Active implanted devices such as intrathecal baclofen pump
- Receiving concurrent electrical stimulation
- Motor threshold evoked by transcutaneous spinal stimulation over 200 mA
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Brooks Rehabilitation Hospital
Jacksonville, Florida, United States, 32216
Actively Recruiting
2
Spaulding Rehabilitation Hospital
Cambridge, Massachusetts, United States, 02128
Actively Recruiting
Research Team
N
Noah Piazza
CONTACT
R
Randy Trumbower, PT, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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