Actively Recruiting
Low-Thoracic Epidural Anesthesia For Laparoscopic Nephrectomy In Adult Patients.
Led by Nazmy Edward Seif · Updated on 2026-01-12
80
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Laparoscopic nephrectomy is a minimally invasive surgery to remove a diseased kidney, offering benefits such as less pain after surgery, shorter hospital stays, quicker return to daily activities, and good cosmetic results similar to open surgery. This research compares two anesthesia methods for this surgery: conventional general anesthesia and regional anesthesia, specifically low-thoracic epidural anesthesia, in adult patients positioned in a modified lateral decubitus with low-pressure pneumoperitoneum. The study aims to evaluate which type of anesthesia may improve patient satisfaction and reduce risks in patients undergoing this procedure. The study involves two groups: one receiving low-thoracic epidural anesthesia, where an epidural catheter is inserted near the lower thoracic spine to deliver a mix of bupivacaine and fentanyl before and during surgery, and the other group receiving general anesthesia with intravenous medications including fentanyl, propofol, atracurium, and lidocaine, followed by maintenance anesthesia with isoflurane and mechanical ventilation. Both methods are applied during the laparoscopic nephrectomy procedure. Participants will be monitored for overall satisfaction 24 hours after surgery. The study also observes the surgical procedure under these anesthetic techniques and collects data on patient outcomes. The trial runs from September 2020 until December 2026 and includes adults aged 18 to 70 years who are scheduled for laparoscopic nephrectomy and classified as ASA I or II, indicating relatively healthy status. Safety and other outcomes related to anesthesia effects will be assessed during the hospital stay.
CONDITIONS
Brief Title
Low-Thoracic Epidural Anesthesia For Laparoscopic Nephrectomy.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- ASA I - II.
- Adult patients scheduled for laparoscopic nephrectomy.
You will not qualify if you...
- Patient refusal.
- Contraindication to regional anesthesia (e.g., coagulopathy, site infection).
- Allergy to local anesthetics.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - Day of surgery
Participants receive either low-thoracic epidural anesthesia or general anesthesia during laparoscopic nephrectomy surgery.
1 visit (in-person)
Duration - 24 hours
Participants are monitored for overall satisfaction and recovery during the 24 hours following surgery.
1 follow-up visit (in-person)
Trial Site Locations
Total: 1 location
1
Cairo University Hospitals
Cairo, Egypt
Actively Recruiting
Research Team
N
Nazmy S Michael, MD
A
Atef K Salama, MD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
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