Actively Recruiting
Low Voltage Electrical Stimulation for Depression in Parkinson's Patients
Led by University of South Alabama · Updated on 2026-04-06
40
Participants Needed
1
Research Sites
151 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to determine the relative efficacy of fMRI model guided Transcranial Direct Current Stimulation (mgTDCS) in improving the depressive symptoms of patients with Parkinson's Disease (PD). The main questions it aims to answer are: 1) Can the use of mgTDCS significantly improve the self-reported level of depression and apathy in patients with PD from pre-intervention to post-intervention compared to a sham control? 2) Can the use of mgTDCS significantly normalize the cortical eeg alpha asymmetry so commonly seen in depressed patients compared to sham mgTDCS? 3) Can the use of mgTDCS significantly improve scores on neuropsychological tests of working memory?
CONDITIONS
Official Title
Low Voltage Electrical Stimulation for Depression in Parkinson's Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Between 19 and 65 years of age
- Parkinson's group must have a physician diagnosis of Parkinson's Disease
- Must have elevated depression with Beck Depression Inventory score of 20 or above
- Must be willing and able to travel to the Psychology Department for EEG and tDCS sessions
- Participants with Deep Brain Stimulation surgery may enroll if advised and monitored by their physician
- Must read and understand spoken English
You will not qualify if you...
- History of or treatment for epilepsy or other seizure disorders
- History of penetrating head wounds or traumatic brain injury greater than mild
- History of atypical Parkinson's disease
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
University of South Alabama
Mobile, Alabama, United States, 36688
Actively Recruiting
Research Team
J
John F Shelley-Tremblay, PhD
CONTACT
B
Benjamin D Hill, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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