Actively Recruiting
Lumbar Drainage of Intraventricular Hemorrhage
Led by University Hospital Heidelberg · Updated on 2026-01-28
354
Participants Needed
12
Research Sites
232 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Intracerebral hemorrhage (ICH) is a debilitating and fatal disease, especially when the hemorrhage is also entering the cerebral ventricles leading to acute hydrocephalus. In these cases, patients need a drainage through external ventricular drains (EVD). In the longer term, patients often need a permanent ventriculoperitoneal (VP) shunt to avoid hydrocephalus. Here we hypothesize that the early insertion of a lumbar drainage in addition to the EVD could lead to better functional outcome and avoidance of VP shunting by drainage of the blood which promotes inflammatory and adverse effects in the subarachnoid space. For that we propose a multi-center randomized clinical trial to investigate the hypothesis.
CONDITIONS
Official Title
Lumbar Drainage of Intraventricular Hemorrhage
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Intracerebral hemorrhage with intraventricular hemorrhage in the 3rd and/or 4th ventricle requiring external ventricular drain placement due to acute hydrocephalus
- Age 18 years or older
- Lumbar drain can be inserted within 72 hours after symptom onset or last seen well
You will not qualify if you...
- Premorbid Modified Rankin Scale score greater than 2
- Pregnancy
- Life expectancy less than 6 months
- Patient, family, or caregiver unwilling or unlikely to opt for at least two weeks of aggressive therapy before comfort measures
- Treating physicians consider prognosis too poor for aggressive therapy
- Other clear contraindications for lumbar drain treatment
AI-Screening
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Trial Site Locations
Total: 12 locations
1
Department of Neurology, University Hospital Heidelberg
Heidelberg, Baden-Wurttemberg, Germany, 69120
Actively Recruiting
2
LMU München
München, Bavaria, Germany
Actively Recruiting
3
Augsburg University Hospital
Augsburg, Germany
Actively Recruiting
4
Charite Universitätsmedizin Berlin
Berlin, Germany
Not Yet Recruiting
5
Düsseldorf Universitiy Hospital
Düsseldorf, Germany
Actively Recruiting
6
Frankfurt University Hospital
Frankfurt, Germany
Not Yet Recruiting
7
Goettingen University Hospital
Göttingen, Germany
Not Yet Recruiting
8
Augsburg University Hospital Department of Neurosurgery
Heidelberg, Germany
Actively Recruiting
9
Heidelberg University Hospital Department of Neurosurgery
Heidelberg, Germany
Actively Recruiting
10
Mainz University Hospital
Mainz, Germany
Not Yet Recruiting
11
Mannheim University Hospital
Mannheim, Germany
Actively Recruiting
12
Osnabrück Clinic
Osnabrück, Germany
Actively Recruiting
Research Team
S
Silvia Schönenberger, MD
CONTACT
M
Min Chen, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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