Randomized Trial of Topical Epidural Steroid Use During 1-2 Level Lumbar Laminectomy Impact on Postoperative Opioid Use, Recovery, and Return to Work

What this Trial Is About

Researchers are evaluating the effects of using topical epidural steroids during surgery for patients undergoing 1- to 2-level lumbar laminectomy. This randomized controlled trial compares the application of 40 mg Depo-Medrol steroid versus sterile normal saline to the surgical wound before closure. The study aims to understand how these treatments affect post-operative opioid use, hospital stay length, return to work, and patient-reported outcomes. Participants are randomly assigned to receive either the steroid Depo-Medrol mixed with a hemostatic matrix or a placebo of sterile normal saline with the matrix applied during surgery. The study includes pre-operative assessment, daily monitoring during hospital stay and for two weeks after discharge, and follow-up visits at 1 and 3 months post-surgery. Both groups are closely observed to compare recovery and pain management outcomes. During the study, participants undergo assessments including opioid consumption tracking, pain rating scales, health surveys, and disability questionnaires before surgery and at multiple points afterward. Researchers also monitor medical complications, hospital readmissions, and return-to-work status. The total participation duration covers pre-surgery evaluation through a three-month follow-up period to capture recovery and treatment effects comprehensively.

Lumbar Steroid Use in Patients Undergoing Posterior Lumbar Decompression