Actively Recruiting
Lumbrokinase for Adults With Long Covid, Post-treatment Lyme Disease Syndrome, and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
Led by Icahn School of Medicine at Mount Sinai · Updated on 2026-03-13
120
Participants Needed
1
Research Sites
111 weeks
Total Duration
On this page
Sponsors
I
Icahn School of Medicine at Mount Sinai
Lead Sponsor
C
Columbia University
Collaborating Sponsor
AI-Summary
What this Trial Is About
This will be a pilot multi-arm clinical trial investigating the feasibility of Lumbrokinase (LK) as an intervention in three clinical cohorts: * Long Covid (LC) * Post-treatment Lyme disease syndrome (PTLDS) * Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)
CONDITIONS
Official Title
Lumbrokinase for Adults With Long Covid, Post-treatment Lyme Disease Syndrome, and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Any gender
- Aged 18 and older
- Baseline EQ-VAS score of 40 or less; EQ-VAS before the infection 80 or higher
- Diagnosed with only one of the following: Long Covid with documented COVID-19 infection at least 3 months ago and physician diagnosis; Post-treatment Lyme disease syndrome meeting Columbia Clinical Trial Network criteria; or Myalgic encephalomyelitis/chronic fatigue syndrome with formal diagnosis before 2020 and symptoms meeting 2011 International Criteria
You will not qualify if you...
- Current use of antiplatelet or anticoagulation medication
- Diagnosis of autoimmune conditions affecting immune profiling such as Chronic EBV, Multiple Sclerosis, or Hashimoto's Disease
- Pregnancy or breastfeeding
- Known allergy to earthworms
- History of bleeding or clotting disorders
- Scheduled surgery during or immediately after the study period
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
The Cohen Center for Recovery from Complex Chronic Illnesses (CoRE)
New York, New York, United States, 10029
Actively Recruiting
Research Team
D
David Putrino, PhD, PT
CONTACT
M
Mackenzie Doerstling, MPH
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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