Actively Recruiting

Age: 18Years +
FEMALE
NCT04142606

LUMIERE on the FETUS

Led by Assistance Publique - Hôpitaux de Paris · Updated on 2025-11-20

1500

Participants Needed

1

Research Sites

390 weeks

Total Duration

On this page

Sponsors

A

Assistance Publique - Hôpitaux de Paris

Lead Sponsor

L

LUMIERE Fondation ( fondation-lumiere.org) under the aegis of Fondation de France

Collaborating Sponsor

AI-Summary

What this Trial Is About

Congenital anomalies are a major public health problem. They affect 2-3% of births, around 20,000 new cases per year in France, of which 15% are cared for in Ile de France. These congenital anomalies are a major cause of morbidity, infant mortality and disability. They are also a major cause of death during the infant period (22% of deaths during the first year of life: source CépiDC Inserm 2010). The detection, accurate diagnosis and accurate prognosis, particularly functional, of these congenital anomalies are still difficult in the current monitoring of pregnancy, which is based primarily on ultrasound. The use and development of modern imaging techniques is now essential to enable doctors to better see and better examine the fetus. Alongside ultrasound, Magnetic Resonance Imaging (MRI) is a technique that has undergone significant development in recent years. MRI must allow the effective anatomical and functional evaluation of the main fetal organs and could in particular be interesting in several situations in which it has not yet been sufficiently evaluated and is not yet performed in clinical routine.

CONDITIONS

Official Title

LUMIERE on the FETUS

Who Can Participate

Age: 18Years +
FEMALE

Eligibility Criteria

Eligible

You may qualify if you...

  • Patient aged 18 years or older
  • Single or twin pregnancy
  • Gestational age between 16 and 36 weeks based on cranio-caudal length dating
  • Patient has given consent to participate
Not Eligible

You will not qualify if you...

  • Any contraindication to MRI
  • More than two fetuses in pregnancy (multiple pregnancies > 2)
  • Follow-up impossible after inclusion
  • Maternal condition that contraindicates continuation of pregnancy
  • Patient requires MRI as part of normal clinical pregnancy care due to identified or suspected fetal abnormalities such as echocardiographic abnormality, diaphragmatic hernia, CMV fetal infection, prior sibling brain abnormality, or surgery for spina bifida (STT)

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

Necker - Enfants Malades Hospital

Paris, France, 75015

Actively Recruiting

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Research Team

D

David Grevent, MD PHD

CONTACT

A

Aminata TRAORE

CONTACT

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

4

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