Actively Recruiting
Luminal Fructose Kinetics (MARTINI Study)
Led by Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Updated on 2024-08-06
22
Participants Needed
1
Research Sites
91 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
In this study the investigators aim is to explore the dynamics of (small) intestinal fructose catabolism in humans and ethanol production in relation to small intestinal signalling pathways and changes in pH, using 13C fructose isotope tracing techniques complemented with direct luminal sampling via small intestinal catheter in biopsy proven MASLD/MASH patients vs healthy (BMI\<25) subjects. Additionally the investigators will repeat the experiment after four weeks of administering omeprazole at a dose of 40 mg twice daily. Omeprazole is a proton pump inhibitor, known to elevate pH from 2-6.
CONDITIONS
Official Title
Luminal Fructose Kinetics (MARTINI Study)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 to 65 years
- Male or postmenopausal females
- For healthy subjects: BMI less than 25
- For MASLD/MASH patients: BMI greater than 25
- Biopsy proven MASLD or MASH for MASLD/MASH group
- Ability to give informed consent
You will not qualify if you...
- History of sustained excess alcohol intake: more than 30g/day for males, more than 20g/day for females
- Diagnosis of diabetes
- Previous bariatric surgery
- Other liver diseases (e.g., Hepatitis B or C, Wilson disease, hemochromatosis)
- Proton pump inhibitor use within one year before the study
- Use of GLP1 agonists, SGLT2 inhibitors, or insulin
- Antibiotic use in the last 3 months
- Use of probiotics or symbiotics
- Pregnancy
- Chronic illnesses including heart failure, renal failure (eGFR less than 30 ml/min), pulmonary, gastrointestinal, or hematologic disorders, or other inflammatory diseases
- Active infection
- Use of platelet inhibitors such as ascal or clopidogrel
- Smoking
- Use of blood thinners
- Heart failure
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Amsterdam UMC location AMC
Amsterdam, Netherlands
Actively Recruiting
Research Team
M
Max Nieuwdorp, Prof
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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