Actively Recruiting
Lung Cancer Screening in HIgh Risk nonsmokErs by Artificial inteLligence Device
Led by Chinese University of Hong Kong · Updated on 2026-03-18
3000
Participants Needed
1
Research Sites
228 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Lung cancer screening is currently not recommended in non-smokers due to paucity of evidence. Emerging evidence suggests that first-degree family history is a strong risk factor for lung cancer in Asian non-smokers. In Asia, lack of resource is a major challenge in successful implementation of lung cancer screening. Artificial intelligence (AI) is a promising tool to overcome this resource. In this study, we aim to study the clinical utility and demonstrate the feasibility of using an AI assisted programme for lung cancer screening in Asian non-smokers with a positive family history. This is a single-arm non-randomized lung cancer screening study. 3000 non-smokers, age 50 to 75 year old, with a first-degree family history of lung cancer, will be enrolled. Participants will undergo low does computed tomography (LDCT) of thorax and blood taking at enrolment. LDCT films will be interpreted by AI softwares for presence of lung nodules. Participants with lung nodules will be further investigated and followed up according to the risk of malignancy. The primary endpoint is the prevalence of early-staged lung cancer detected by first-round LDCT thorax in this population.
CONDITIONS
Official Title
Lung Cancer Screening in HIgh Risk nonsmokErs by Artificial inteLligence Device
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 50-75 years old
- Non-smoker (less than 100 cigarettes in lifetime)
- First-degree family history of lung cancer
- Physically fit for curative treatment if early-stage lung cancer is found
- Able to provide written informed consent
- Agree to follow-up visits and CT scans if needed
- Agree to blood tests for research
You will not qualify if you...
- History of any malignancy
- Smoking history of more than 100 cigarettes in lifetime
- Symptoms suspicious for lung cancer (e.g., coughing blood, chest pain, weight loss)
- Medical conditions preventing curative lung cancer treatment (e.g., severe heart disease, respiratory failure, bleeding disorders)
- Pregnant or planning pregnancy
- History of tuberculosis or interstitial lung disease
- Pneumonia treated with antibiotics in past 12 weeks
- Chest CT or related imaging done within past 2 years
- Unable or unwilling to provide written informed consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Department of Clinical Oncology, Prince of Wales Hospital
Hong Kong, Hong Kong
Actively Recruiting
Research Team
M
Molly SC LI, MBBS, MRCP
CONTACT
C
Candy TANG, PC
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
SCREENING
Number of Arms
1
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