Actively Recruiting
Lung Microbiome and Inflammation in Early COPD
Led by NYU Langone Health · Updated on 2026-01-28
230
Participants Needed
1
Research Sites
848 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a cross sectional case controlled study to assess lung microbiome and inflammation in smokers with and without Chronic Obstructive Pulmonary Disease (COPD). Investigators will look at active bacterial metabolic pathways in the lower airways using metagenomic and metabolomic approaches an assess relationships among microbiome, metagenome, metabolome and host immune responses in COPD and controls. Investigators believe COPD cases will have higher prevalence of pneumotype supraglottic predominant taxa (SPT) than matched controls.
CONDITIONS
Official Title
Lung Microbiome and Inflammation in Early COPD
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Smokers with more than 20 pack-years and airflow obstruction defined by FEV1/FVC less than 70% and FEV1 greater than 50% predicted (early COPD GOLD 1 or 2)
- Smokers with normal lung function will serve as controls
You will not qualify if you...
- FEV1 less than 50%
- Significant cardiovascular disease including abnormal EKG, known or suspected coronary artery disease, or congestive heart failure
- Diabetes mellitus
- Significant liver or renal disease
- Severe coagulopathy (INR greater than 1.4, PTT greater than 40 seconds, and platelet count less than 150,000 cells)
- Pregnancy
- Alcohol use exceeding 6 beers or 4 mixed drinks daily
- Inability to provide informed consent
- Antibiotic use within the prior 2 months
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
New York University School of Medicine
New York, New York, United States, 10016
Actively Recruiting
Research Team
R
Rosemary Schluger
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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