Actively Recruiting
Lung Protective Ventilation and Driving Pressure Guided PEEP Titration in CABG Surgery
Led by Kocaeli University · Updated on 2025-08-08
86
Participants Needed
1
Research Sites
110 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Our aim in this study is to compare fixed and individualized PEEP (driving pressure guided ) application for intraoperative lung protective ventilation in patients undergoing on-pump CABG surgery. Researcher aimed to compare the effects of two different PEEP application methods on intraoperative hemodynamics, respiratory mechanics, and gas exchange, as well as postoperative extubation times, respiratory complications (atelectasis, need for non invasive mechanical ventilatıon, need for re-entubatıon) length of stay in the intensive care unit, and discharge times.
CONDITIONS
Official Title
Lung Protective Ventilation and Driving Pressure Guided PEEP Titration in CABG Surgery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients scheduled for elective on-pump coronary artery bypass graft surgery via median sternotomy
- Patients between the ages of 18 and 70
- ASA (American Society of Anesthesiologists) physical status classification II-III
You will not qualify if you...
- Patients with an ejection fraction below 35%
- Patients who did not consent to participate in the study
- Patients undergoing emergency surgery
- Patients who are allergic to the anesthetic drugs used
- Patients who have undergone lung resection
- Those with a history of mechanical ventilation in the 2 months before surgery
- Patients who have undergone total circulatory arrest and deep hypothermia
- Patients with obstructive sleep apnea syndrome requiring long-term ventilation assistance
- Morbid obesity (Body Mass Index >35kg/m2)
- Patients with refractory hypoxemia (arterial oxygen saturation below 88% despite 100% oxygen inhalation)
- COPD (FEV1 <70%)
- Patients with chronic renal failure (serum creatine >1.8 mg/dl)
- Anemia (Hg <10 gr/dl)
- Patients who have had an intraaortic balloon pump placed
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Kocaeli University Faculty of Medicine
Kocaeli, izmit, Turkey (Türkiye), 41100
Actively Recruiting
Research Team
Z
Zeynep Açık, MD
CONTACT
T
Tülay Çardaközü, PROFESSOR
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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