Actively Recruiting
Evaluation of Lung Recruitment During Chest Physiotherapy in Mechanically Ventilated Patients
Led by Assistance Publique - Hôpitaux de Paris · Updated on 2026-01-15
40
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating the effects of respiratory physiotherapy in patients who are under invasive mechanical ventilation in intensive care. This study compares the lung recruitment and other respiratory effects during chest physiotherapy sessions performed under two different ventilatory modes: Volume Assist Control Ventilation (V-ACV) and pressure support ventilation (PSV). The goal is to understand how ventilatory settings influence physiotherapy outcomes, especially in patients with abundant mucus requiring airway clearance. Participants receive a standardized respiratory physiotherapy intervention consisting of rib cage compressions applied to the chest while positioned supine with the head of the bed elevated to 35 degrees. Each patient undergoes two sessions in one day — one in the morning and one in the afternoon — with one session performed under V-ACV and the other under PSV, in randomized order. The sessions involve 7 series of 3 brief, vigorous compressions during expiration, spaced by about 10 respiratory cycles. During the study, researchers measure lung volume changes, oxygen levels, respiratory mechanics, mucus volume and weight, regional lung ventilation, heart rate, blood pressure, and other breathing parameters before, during, and after each physiotherapy session. Measurements are taken at specific times including 5 minutes before, during, immediately after, and up to 1 hour following sessions. This detailed monitoring helps assess the effectiveness and patient tolerance of the physiotherapy under different ventilatory modes.
CONDITIONS
Brief Title
Lung Recruitment During Chest Physiotherapy in Mechanically Ventilated Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patient under assisted ventilation (V-ACV or PSV) triggering all ventilator cycles
- Requires 2 or more tracheal suctionings every 3 hours
- Has given consent to participate (patient or relative)
- Covered by social security
You will not qualify if you...
- Under 18 years old
- Requires a legal guardian
- Recent cardiac, thoracic, or abdominal surgery within the last 3 months
- Rib fractures
- Pneumothorax or presence of a chest drain
- Recent neurosurgery within the last 3 months or increased intracranial pressure
- Hemodynamic instability with specified medication dosages
- Respiratory instability defined by PEEP >10 cmH2O or PaO2/FiO2 <150 mm Hg
- Pregnancy
- Hemoptysis
- Severe skin lesions such as burns or Lyell's syndrome
- Covered by foreign health insurance
AI-Screening
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Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 1 day
Participants receive two standardized respiratory physiotherapy sessions with Rib Cage Compressions (RCC) on the same day, one session in the morning under V-ACV ventilation mode and one session in the afternoon under PSV ventilation mode. Each session involves 7 series of 3 Rib Cage Compressions applied to the thorax while positioned supine with head elevation at 35 degrees.
2 sessions in one day (morning and afternoon)
Trial Site Locations
Total: 1 location
1
Intensive Care Medicine Department Henri Mondor Hospital
Créteil, France, 94000
Actively Recruiting
Research Team
G
Guillaume Pr CARTEAUX, MD,PhD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
OTHER
Number of Arms
2
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