Actively Recruiting

Phase Not Applicable
Age: 18Years - 100Years
All Genders
NCT06805357

Lung Recruitment During Chest Physiotherapy in Mechanically Ventilated Patients

Led by Assistance Publique - Hôpitaux de Paris · Updated on 2026-01-15

40

Participants Needed

1

Research Sites

152 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

In intensive care, respiratory physiotherapy is an integral part of the daily care of patients under invasive mechanical ventilation. Its goals are to improve the clearance of bronchial secretions to allow for the resolution of atelectasis and alveolar recruitment, thereby enhancing respiratory mechanics and gas exchange. The most widespread technique in France is external expiratory compression of the chest. The effectiveness of this technique depends on the selection of patients (it seems to be more effective in patients with higher secretion levels) and on the practical implementation of the technique (favoring brief and vigorous compressions at the beginning of expiration). However, the effect of the artificial ventilator settings, particularly the ventilatory mode used during the respiratory physiotherapy session, has never been evaluated. The two most commonly used ventilatory modes worldwide are Volume Assist Control Ventilation (V-ACV) and pressure support ventilation (PSV). In this unit, respiratory physiotherapy under artificial ventilation is performed daily on patients with artificial ventilation with abundant secretions, regardless of the ventilatory mode.

CONDITIONS

Official Title

Lung Recruitment During Chest Physiotherapy in Mechanically Ventilated Patients

Who Can Participate

Age: 18Years - 100Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Patient under assisted ventilation (in V-ACV or PSV) triggering all ventilator cycles
  • Patient deemed " secretive ": requiring 62 2 tracheal aspirations every 3 hours
  • Patient (or relative) who has given consent to participate in the research
  • Patient covered by social security
Not Eligible

You will not qualify if you...

  • Age under 18 years
  • Legal guardian required
  • Recent cardiac and/or thoracic and/or abdominal surgery (< 3 months)
  • Rib fracture(s)
  • Pneumothorax and/or presence of a chest drain
  • Recent neurosurgery (< 3 months) and/or proven or suspected increased intracranial pressure (ICP)
  • Hemodynamic instability defined as: noradrenaline 62 1mg/h, adrenaline 62 0.5 mg/h, dobutamine 62 5b3/kg/min.
  • Respiratory instability defined as: PEEP > 10 cmH2O and/or PaO2/FiO2 < 150 mm Hg
  • Pregnancy
  • Hemoptysis
  • Sever skin lesions (e.g., burns, Lyell's syndrome)
  • Patient under foreign health insurance

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

Intensive Care Medicine Department Henri Mondor Hospital

Créteil, France, 94000

Actively Recruiting

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Research Team

G

Guillaume Pr CARTEAUX, MD,PhD

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

RANDOMIZED

Model

CROSSOVER

Primary Purpose

OTHER

Number of Arms

2

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