Actively Recruiting
Lung Ultrasound-Guided Fluid Deresuscitation in ICU Patients
Led by Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Updated on 2025-12-05
1000
Participants Needed
3
Research Sites
231 weeks
Total Duration
On this page
Sponsors
A
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Lead Sponsor
Z
ZonMw: The Netherlands Organisation for Health Research and Development
Collaborating Sponsor
AI-Summary
What this Trial Is About
Timely recognition and treatment of fluid overload can expedite liberation from invasive mechanical ventilation in intensive care unit (ICU) patients. Lung ultrasound (LUS) is an easy to learn, safe, cheap and noninvasive bedside imaging tool with high accuracy for pulmonary edema and pleural effusions in ICU patients. The aim of this study is to assess the effect of LUS-guided deresuscitation on duration of invasive ventilation in ICU patients. The investigators hypothesize that LUS-guided fluid deresuscitation is superior to routine fluid deresuscitation (not using LUS) with regard to duration of invasive ventilation. This study is an international multicenter randomized clinical trial (RCT) in invasively ventilated ICU patients.This study will include 1,000 consecutively admitted invasively ventilated adult ICU patients, who are expected not to be extubated within the next 24 hours after randomization. Patients are randomly assigned to the intervention group, in which fluid deresuscitation is guided by repeated LUS, or the control group, in which fluid deresuscitation is at the discretion of the treating physician (not using LUS).
CONDITIONS
Official Title
Lung Ultrasound-Guided Fluid Deresuscitation in ICU Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Admission to one of the participating ICUs
- Invasively ventilated for less than 24 hours at randomization
- Expected to be under invasive ventilation for longer than 24 hours after randomization
You will not qualify if you...
- Age below 18 years old
- Suspected or confirmed pregnancy
- Participation in other interventional trials with similar endpoints
- Use of long term home mechanical ventilation
- Neurological conditions that can prolong ventilation duration (e.g., Guillain-Barré syndrome, high spinal cord lesion, amyotrophic lateral sclerosis, multiple sclerosis, myasthenia gravis)
- Conditions preventing accurate lung ultrasound (e.g., chest wall abnormalities, morbid obesity, pre-existing interstitial lung disease)
- Conditions where targeting negative fluid balance is discouraged (e.g., subarachnoid bleeding, severe rhabdomyolysis with CK > 20,000)
- Previous participation in this trial
- Patients transferred from another center and ventilated invasively for longer than 24 hours
AI-Screening
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Trial Site Locations
Total: 3 locations
1
Rijnstate
Arnhem, Gelderland, Netherlands, 6800 TA
Actively Recruiting
2
Amsterdam UMC, location VUMC
Amsterdam, North Holland, Netherlands, 1081 HV
Actively Recruiting
3
Amsterdam UMC, location AMC
Amsterdam, North Holland, Netherlands, 1105AZ
Actively Recruiting
Research Team
A
Amne Mousa, MSc
CONTACT
S
Siebe G Blok, MD, MSc
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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