Lung Ventilation and Perfusion Differences and Prognostic Importance in Chronic Critical Illness Patients on Prolonged Mechanical Ventilation

What this Trial Is About

This research aims to analyze physiological and clinical data from patients with chronic critical illness who require prolonged mechanical ventilation and have undergone tracheostomy. The goal is to identify different patient characteristics through various physiological measurements, which may help develop tailored clinical strategies to assist patients in being freed from mechanical ventilation. Participants must have been on mechanical ventilation for at least 10 days in the intensive care unit and then transferred to a specialized respiratory care center for weaning training. All participants have a tracheotomy tube and are in stable respiratory condition with an inspired oxygen fraction of 50% or less. The study focuses on understanding lung ventilation and perfusion differences among patient phenotypes during this weaning process. During the study, researchers will track the participants' ability to be liberated from mechanical ventilation, specifically monitoring liberation at discharge from the weaning unit within five days. Participants will undergo various physiological measurements, and their clinical progress will be observed to understand prognostic differences related to lung function and patient phenotypes. The total involvement period focuses on the weaning phase in the respiratory care center.

Lung Ventilation and Perfusion in Different Phenotypes of Chronic Critical Illness With Prolonged Mechanical Ventilation