Actively Recruiting
The Role of Lutein, Zeaxanthin, and Fish Oil on Cognitive Function and Bone Health in Healthy Adults
Led by Texas A&M University · Updated on 2025-09-30
80
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
T
Texas A&M University
Lead Sponsor
A
Allen Foundation Inc.
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are studying the effects of lutein, zeaxanthin, and fish oil (LZF) supplements on healthy adults aged 18 to 45 who have low macular pigment optical density (MPOD). The trial aims to find out if taking LZF for six months can improve MPOD, cognitive performance, and bone density compared to a placebo. The study uses a precision nutrition model to address risks related to aging, including macular degeneration, cognitive decline, and bone loss. Participants will be randomly assigned to take either a daily LZF supplement containing 7 mg lutein, 14 mg zeaxanthin, and 245 mg fish oil or a placebo supplement. This treatment lasts for six months. The study is double-blind and controlled, meaning neither participants nor researchers know who receives the supplement or placebo. During the trial, participants will undergo assessments at the start, three months, and six months. These include measuring MPOD, cognitive performance using Neurotracker software, bone density via DXA scans, fasting blood samples, and serum levels of lutein and zeaxanthin. Researchers will track changes over time to understand the impact of the supplements on vision, thinking skills, and bone health.
CONDITIONS
Brief Title
Lutein, Zeaxathin, and Fish Oil Supplementation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 to 45 years
- Macular pigment optical density (MPOD) less than 0.43
- Self-reported best-corrected vision of 20/40 or better in each eye
- Body mass index (BMI) between 18.5 and 30
- Meets inclusion criteria on the preliminary participant questionnaire
You will not qualify if you...
- Allergy to lutein, zeaxanthin, or fish oil
- Taking supplements with more than 6 mg lutein or more than 2 mg zeaxanthin for over two months before study start
- MPOD greater than 0.43
- Self-reported vertigo
- Diabetic retinopathy
- Retinitis pigmentosa
- Optic neuropathy
- Retinal vascular occlusions
- Strabismus
- Autoimmune disorders related to visual health
- Currently pregnant or trying to become pregnant
- History of concussion
- Vegan diet (due to gelatin in placebo)
- Taking neuroactive medications such as Ritalin, Adderall, or antidepressants
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person) to assess eligibility including macular pigment optical density (MPOD) and other criteria
Duration - 6 months
Participants take a daily supplement of lutein, zeaxanthin, and fish oil or a placebo for six months.
Visits at baseline, 3 months, and 6 months with multiple assessments including blood draws, MPOD, bone density, and cognitive performance
Trial Site Locations
Total: 1 location
1
Gilchrist Building
College Station, Texas, United States, 77843
Actively Recruiting
Research Team
K
Karen M Beathard, PhD
S
Steven E Riechman, PhD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
2
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