Study of Lymph Node Changes in Adults With Cat Allergies Receiving or Not Receiving Cat Allergen Immunotherapy

What this Trial Is About

Researchers are studying how the immune system responds to cat allergens in people with cat allergies, focusing on those who are receiving cat allergen immunotherapy and those who are not. This early phase 1 trial aims to understand the number of immune cells in lymph nodes after a controlled exposure to cat allergen, which may help improve allergy treatments in the future. The study has two groups one group of participants who have been receiving subcutaneous immunotherapy SCIT for at least one year, and another group who have never had cat immunotherapy. Both groups will receive an intradermal cat allergen challenge on both upper arms on Day 1. Participants will have lymph node and blood samples taken on Day 4 and again at Week 3. Additional samples from adenoid and nasal areas will also be collected at Week 3. Lymph node sampling alternates between axillary sites at these time points. Participants will be involved in several visits over three weeks, including allergen challenges, fine-needle aspirations of lymph nodes, blood draws, and nasal and adenoid sample collections. Researchers will measure the total number of analyzable cells from lymph node samples taken at Day 4 and Week 3. They will also monitor any adverse events related to lymph node sampling and adenoid swabs throughout the study. The study will last from baseline through Week 3, with safety follow-up included during this period.

LYmph Node eXamination in Cat Allergen Immunotherapy