Actively Recruiting
The LYMPH Trial - Microsurgical Versus Conservative Treatment of Chronic Breast Cancer Associated Lymphedema
Led by University Hospital, Basel, Switzerland · Updated on 2025-11-14
280
Participants Needed
35
Research Sites
672 weeks
Total Duration
On this page
Sponsors
U
University Hospital, Basel, Switzerland
Lead Sponsor
S
Swiss National Science Foundation
Collaborating Sponsor
AI-Summary
What this Trial Is About
The aim of this study is to test whether lymphatic surgery provides better QoL (assessed with the Lymph-ICF-UL, (Lymphedema Functioning Disability and health questionnaire for upper limb lymphedema)) 15 months after randomization (and therefore about one year after surgery) compared to conservative treatment only for patients with chronic lymphedema (LE)
CONDITIONS
Official Title
The LYMPH Trial - Microsurgical Versus Conservative Treatment of Chronic Breast Cancer Associated Lymphedema
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Written informed consent.
- Patients 18 years of age or older.
- Previous diagnosis of breast cancer.
- Clinical diagnosis of chronic Breast Cancer-Related Lymphedema persisting over 3 months, stage 1 or higher according to ISL.
- At least 3 months of Conservative Complex Physical Decongestion Therapy.
- Ability to complete quality of life questionnaires.
- Willingness to undergo surgery.
You will not qualify if you...
- No indication for lymphatic surgery based on the treating surgeon's clinical judgment.
- Primary congenital lymphedema or lymphedema not related to breast cancer.
- Previous surgical treatment for breast cancer-related lymphedema on the intended side of intervention.
AI-Screening
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Trial Site Locations
Total: 35 locations
1
Yale School of Medicine
New Haven, Connecticut, United States, 06510
Not Yet Recruiting
2
Harvard Medical School
Boston, Massachusetts, United States, 02115
Not Yet Recruiting
3
Washington University School of Medicine in St. Louis
St Louis, Missouri, United States, 63110
Actively Recruiting
4
Mayo Clinic
Rochester, New York, United States, 55905
Not Yet Recruiting
5
Krankenhaus Göttlicher Heiland GmbH
Vienna, Austria, A-1170
Not Yet Recruiting
6
Brussels University Hospital
Brussels, Jette, Belgium, 1090
Not Yet Recruiting
7
University of Ghent
Ghent, Belgium, 9000
Actively Recruiting
8
Hospital Erasto Gaertner
Paraná, Curitiba, Brazil, 80730-001
Not Yet Recruiting
9
McGill University, Royal Victoria Hospital
Montreal, Canada, QC H4A 3J1
Actively Recruiting
10
University of British Columbia, Gordon and Leslie Diamond Health Care Centre
Vancouver, Canada, BC V5Z 1M9
Actively Recruiting
11
BG Universitätsklinikum Bergmannsheil Bochum
Bochum, Germany, 44789
Actively Recruiting
12
Sana Kliniken Düsseldorf
Düsseldorf, Germany, 40593
Actively Recruiting
13
Uniklinikum Erlangen
Erlangen, Germany, 91054
Actively Recruiting
14
KEM Evang. Kliniken Essen-Mitte
Essen, Germany, 45136
Actively Recruiting
15
BG Klinik Frankfurt am Main
Frankfurt, Germany, 60389
Actively Recruiting
16
Universitätsklinikum Freiburg, Klinik für Plastische und Handchirurgie
Freiburg im Breisgau, Germany, 79106
Actively Recruiting
17
BG Klinik Ludwigshafen
Ludwigshafen am Rhein, Germany, 67071
Actively Recruiting
18
Klinikum Nürnberg
Nuremberg, Germany, 90419
Actively Recruiting
19
Caritas Krankenhaus St. Josef/ Uniklinik Regensburg
Regensburg, Germany, 93053
Actively Recruiting
20
Papageorgiou Hospital of Thessaloniki
Thessaloniki, Greece, 55133
Actively Recruiting
21
Rambam Health Clinic, ISR
Haifa, Israel, 3109601
Not Yet Recruiting
22
Policlinico Tor Vergata: Fondazione PTV
Rome, Italy, 00133
Not Yet Recruiting
23
Policlinico Universitario Fondazione Agostino Gemelli
Rome, Italy, 00168
Actively Recruiting
24
Maastricht University Medical Center
Maastricht, Netherlands, 6202
Actively Recruiting
25
Institute of Oncology ''Prof. Dr. Ion Chiricuță'' of Cluj-Napoca
Cluj-Napoca, Romania, 400015
Actively Recruiting
26
Hospital de la Santa Creu i Sant Pau
Barcelona, Spain, 08025
Actively Recruiting
27
Karolinska Institutet, K1 Molekylär medicin och kirurgi
Stockholm, Sweden, 17176
Not Yet Recruiting
28
Department of Plastic and Reconstructive Surgery Uppsala University Hospital
Uppsala, Sweden, 751 85
Actively Recruiting
29
Kantonsspital Aarau
Aarau, Switzerland, 5001
Actively Recruiting
30
University Hospital Basel
Basel, Switzerland, 4031
Actively Recruiting
31
Hôpitaux Universitaires de Genève
Geneva, Switzerland, 1205
Actively Recruiting
32
Centre Hospitalier Universitaire Vaudois
Lausanne, Switzerland, 1011
Actively Recruiting
33
Kantonsspital Winterthur
Winterthur, Switzerland, 8401
Actively Recruiting
34
Klinik für Plastische, Rekonstruktive, Aesthetische und Handchirurgie
Zurich, Switzerland, 8091
Actively Recruiting
35
Kaohsiung Chang Gung Memorial Hospital
Kaohsiung City, Taiwan, 833
Not Yet Recruiting
Research Team
E
Elisabeth Kappos, Prof. Dr.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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