Actively Recruiting
Lymphovenous Bypass Procedure Before Underarm Lymph Node Surgery in Preventing Lymphedema in Patients With Inflammatory or Locally Advanced Non-inflammatory Breast Cancer or Melanoma
Led by M.D. Anderson Cancer Center · Updated on 2025-11-10
252
Participants Needed
1
Research Sites
385 weeks
Total Duration
On this page
Sponsors
M
M.D. Anderson Cancer Center
Lead Sponsor
N
National Cancer Institute (NCI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This pilot trial studies whether a procedure called lymphovenous bypass would prevent lymphedema (arm swelling) in patients with inflammatory breast cancer or non-inflammatory breast cancer that has spread to nearby tissues or lymph nodes or melanoma. The lymphovenous bypass procedure creates a path for lymphatic fluid to flow away from the arms. It is usually done after a diagnosis of lymphedema. In this study, giving lymphovenous bypass before underarm lymph node surgery may help prevent lymphedema from forming.
CONDITIONS
Official Title
Lymphovenous Bypass Procedure Before Underarm Lymph Node Surgery in Preventing Lymphedema in Patients With Inflammatory or Locally Advanced Non-inflammatory Breast Cancer or Melanoma
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients 18 years of age or older
- Willingness to participate in the study
- Ability to provide informed consent
- Diagnosis of inflammatory breast cancer or locally advanced non-inflammatory breast cancer undergoing axillary lymph node dissection (ALND) with anticipated radiation therapy
- Or diagnosis of melanoma (including unknown primary) scheduled for ALND as a comparator group
You will not qualify if you...
- Use of anticoagulants within 7 days before surgery
- Known pregnancy at time of surgery
- Inability to complete follow-up visits or measurements within 18 months
- Body mass index (BMI) greater than 50.0
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
M D Anderson Cancer Center
Houston, Texas, United States, 77030
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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