Actively Recruiting
Lynch Syndrome Integrative Epidemiology and Genetics
Led by University of Colorado, Denver · Updated on 2025-01-15
5000
Participants Needed
2
Research Sites
1578 weeks
Total Duration
On this page
Sponsors
U
University of Colorado, Denver
Lead Sponsor
U
University of Chicago
Collaborating Sponsor
AI-Summary
What this Trial Is About
The vision of the "Lynch syndrome INtegrative Epidemiology And GEnetics" (LINEAGE) Consortium is to collaboratively improve the lives and longevity of individuals and families with Lynch syndrome. The mission of the LINEAGE Consortium is to collaboratively improve Lynch syndrome care through high-quality research. This consortium will provide intellectual and infrastructure support to facilitate development of research questions, collection of standardized data and biospecimens, support of grant applications, and generation of collaborative manuscripts. Our aims are to: I. Establish a prospective cohort of individuals with Lynch syndrome II. Collect standardized longitudinal clinical and biosample data to elucidate Lynch Syndrome epidemiology and gene-host interactions III. Promote intervention trials to improve cancer prevention and early detection in Lynch Syndrome
CONDITIONS
Official Title
Lynch Syndrome Integrative Epidemiology and Genetics
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults age over 18 years
- Must have at least one variant of uncertain significance, pathogenic, or likely pathogenic variant in MLH1, MSH2, MSH6, PMS2, or EPCAM confirmed by genetic testing and ClinVar review
- Individuals who are obligate carriers of a Lynch Syndrome pathogenic or likely pathogenic variant confirmed in the family
You will not qualify if you...
- Under 18 years of age
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
University of Colorado
Aurora, Colorado, United States, 80045
Actively Recruiting
2
University of Chicago
Chicago, Illinois, United States, 60637
Not Yet Recruiting
Research Team
S
Swati G Patel, MD, MS
CONTACT
S
Sonia Kupfer, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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