Study of Immune System Role in Colorectal Cancer Development in Adults with Lynch Syndrome

What this Trial Is About

Lynch syndrome is a common inherited condition that increases the risk of colorectal and endometrial cancers, among others, due to genetic mutations affecting DNA repair. Despite regular cancer screenings, many patients still develop colorectal cancer, and the reasons behind this are unclear. This research investigates the interaction between the intestinal lining and the immune system to better understand early cancer development and identify biological markers and processes that may help in prevention. The study analyzes blood, mucosal tissue, and hair samples to measure microRNAs, antibodies against specific peptides, bacteria present in colon tissue, and environmental exposures to carcinogens. Participants include groups with Lynch syndrome gene mutations both with and without colorectal cancer or advanced adenomas, as well as individuals without these mutations but with various colorectal conditions. This observational study looks at immune and microbiome profiles to find early signs of cancer and better understand disease mechanisms. Participants will undergo regular clinical evaluations, including gastrointestinal endoscopy and sample collection of blood, mucosa, and hair. Researchers will assess immune responses, tumor microbiomes, and environmental factors, measuring outcomes such as sensitivity and specificity of biomarkers over about one year. The study aims to improve early cancer detection and prevention strategies by closely monitoring biological indicators and immune surveillance in high-risk individuals.

Lynch Syndrome X-Talk of Enteral Mucosa With Immune System