Actively Recruiting
Machine Learning Approaches to Personalized Therapy for Advanced Non-small Cell Lung Cancer With Real-World Data
Led by University of Utah · Updated on 2026-05-04
144400
Participants Needed
1
Research Sites
156 weeks
Total Duration
On this page
Sponsors
U
University of Utah
Lead Sponsor
P
Patient-Centered Outcomes Research Institute
Collaborating Sponsor
AI-Summary
What this Trial Is About
This research will leverage machine learning (ML) and causal inference techniques applied to real-world data (RWD) to generate evidence that personalizes treatment strategies for patients with advanced non-small cell lung cancer (aNSCLC). Rather than influencing regulatory decisions or clinical guidelines, the goal of this trial is to refine treatment selection among existing therapeutic options, ensuring that care is tailored to individual patient characteristics. Additionally, by generating real-world evidence, these findings will inform the design and implementation of future clinical trials. Importantly, the methodological advancements will establish a pipeline that extends beyond aNSCLC, facilitating the identification of optimal dynamic treatment regimes (DTRs) for other complex diseases.
CONDITIONS
Official Title
Machine Learning Approaches to Personalized Therapy for Advanced Non-small Cell Lung Cancer With Real-World Data
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosed with advanced NSCLC between January 1, 2011, and June 30, 2024.
- Follow-up available until December 31, 2024, with a minimum potential follow-up period of at least six months.
You will not qualify if you...
- Less than one day of follow-up after starting first-line therapy.
- Presence of a targetable mutation including ALK, BRAF, EGFR, KRAS, or ROS1.
- PD-L1 expression less than 50% at baseline (for patients with PD-L1 50%).
- First-line treatment limited to immunotherapy or chemoimmunotherapy only.
- Receiving second-line treatment or enrolled in a clinical study.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Huntsman Cancer Institute at the University of Utah
Salt Lake City, Utah, United States, 84112
Actively Recruiting
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
4
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here