Actively Recruiting
Macrophage Regulation of Ozone-Induced Lung Inflammation
Led by Robert Tighe, MD · Updated on 2025-09-05
100
Participants Needed
1
Research Sites
258 weeks
Total Duration
On this page
Sponsors
R
Robert Tighe, MD
Lead Sponsor
N
National Institutes of Health (NIH)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this research study to understand how prior respiratory infections affect the susceptibility to lung inflammation following environmental exposures.
CONDITIONS
Official Title
Macrophage Regulation of Ozone-Induced Lung Inflammation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Individuals between 18 and 55 years of age (no exclusion based on gender or ethnicity)
- Individuals with knowledge of prior SARS-CoV-2 infection history to be assigned to one of three cohorts:
- Cohort 1: No history of SARS-CoV-2 infection (no symptoms or positive test)
- Cohort 2: Documented mild SARS-CoV-2 infection with mild/no symptoms and no lower respiratory infection
- Cohort 3: History of SARS-CoV-2 infection with symptoms/imaging of lower respiratory infection, recovered, more than 6 months since infection, normal lung function
- Minimal period of more than 6 months since SARS-CoV-2 infection for inclusion
You will not qualify if you...
- Individuals with prior SARS-CoV-2 pneumonia who have ongoing respiratory symptoms, use supplemental oxygen, or abnormal lung function
- Individuals with prior SARS-CoV-2 infection without documentation of a positive test
- Current smokers or those who smoked within the past 5 years
- Pregnant women and currently lactating women
- Recent antibiotic use or upper respiratory infection within 4 weeks
- College or graduate students or employees directly supervised by study investigators
- Alcohol or illicit substance abuse
- Chronic cardio/pulmonary disorders or other medical conditions per investigator
- Increased airway hyperresponsiveness at baseline (positive methacholine challenge)
- Use of antihistamines, NSAIDs, antioxidants, or supplemental vitamins within 1 week prior to and during testing
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Duke University Medical Center
Durham, North Carolina, United States, 27710
Actively Recruiting
Research Team
C
Claudia Salazar
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
NON_RANDOMIZED
Model
CROSSOVER
Primary Purpose
OTHER
Number of Arms
3
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