Actively Recruiting

Phase 2
Age: 18Years +
All Genders
NCT05730816

MAGIC AKI: Magnesium for the Prevention of HIOC-Associated AKI

Led by Brigham and Women's Hospital · Updated on 2025-11-21

130

Participants Needed

1

Research Sites

247 weeks

Total Duration

On this page

Sponsors

B

Brigham and Women's Hospital

Lead Sponsor

N

National Institutes of Health (NIH)

Collaborating Sponsor

AI-Summary

What this Trial Is About

In this research study, investigators will test whether prophylactic high-dose IV Mg administration attenuates the risk of AKI in patients with malignant mesothelioma receiving intraoperative chemotherapy (HIOC) with cisplatin compared to placebo .

CONDITIONS

Official Title

MAGIC AKI: Magnesium for the Prevention of HIOC-Associated AKI

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Adult patients (18 years or older) with malignant mesothelioma
  • Undergoing surgery with hyperthermic intraoperative chemotherapy with cisplatin performed by Dr. Raphael Bueno or another BWH thoracic surgeon
Not Eligible

You will not qualify if you...

  • Estimated glomerular filtration rate (eGFR) below 45 ml/min/1.73m2 on screening or preoperative labs, or end-stage kidney disease requiring renal replacement therapy
  • Serum magnesium level higher than 3 mg/dl on screening or preoperative labs
  • Pregnant or breastfeeding
  • Neuromuscular diseases such as myasthenia gravis, amyotrophic lateral sclerosis, multiple sclerosis, muscular dystrophy, or myositis
  • Coronary artery disease within the past year, including positive stress test, significant vessel stenosis, stents placement, or bypass surgery
  • Sinus bradycardia with heart rate below 55 bpm on any ECG in the past 6 months
  • High-grade atrioventricular block (2nd degree type II or 3rd degree) without a pacemaker
  • Positive COVID-19 test within 10 days before surgery
  • Prisoner status
  • Known hypersensitivity to magnesium sulfate
  • Participation in another study with experimental therapy that might interact with intravenous magnesium
  • Any condition that might increase risk or affect study integrity as judged by the principal investigator
  • Conflicts with other studies

AI-Screening

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Trial Site Locations

Total: 1 location

1

Brigham and Women's Hospital

Boston, Massachusetts, United States, 02130

Actively Recruiting

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Research Team

S

Shruti Gupta, MD, MPH

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

PREVENTION

Number of Arms

2

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