Actively Recruiting
Magnesium Infusion for Pain Management in Critically Ill Trauma Patients
Led by University of California, Davis · Updated on 2025-11-26
156
Participants Needed
1
Research Sites
368 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Magnesium is a naturally occurring mineral that is important for your body and brain. Magnesium sulfate (study drug) is a medication containing magnesium that is commonly used to improve low blood levels of magnesium. Magnesium sulfate has also proven to be successful in managing pain before and after surgery. However, this drug has primarily been used for pain control in patients undergoing surgery. Patients in the ICU with injuries also need good pain control. Using magnesium may assist in decreasing narcotic (pain reliever) requirements and provide another non-narcotic drug for pain control. The purpose of this study is to test the effectiveness of continuous, intravenous (into or within a vein using a needle) administration of magnesium sulfate for pain control in trauma patients admitted to the adult Intensive Care Unit. This will be compared to intravenous normal saline (salt solution).
CONDITIONS
Official Title
Magnesium Infusion for Pain Management in Critically Ill Trauma Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- All trauma patients admitted to an adult intensive care unit
- Signed informed consent
- Hospital or trauma multimodal pain management order set used for pain management
- Ages 18-99
You will not qualify if you...
- Admission to the Pediatric Intensive Care Unit
- Head Abbreviated Injury Score (AIS) greater than 1
- Known heart failure with reduced ejection fraction (EF < 40%)
- Renal failure (GFR < 60)
- Cardiac arrhythmia (except for sinus tachycardia)
- Greater than 5% total body surface area burn injuries
- Moderate to severe alcohol withdrawal protocol ordered
- Regular use of opioids in the week prior to injury
- Receiving continuous infusion of opioids
- Expected to require general anesthesia between 24 and 48 hours after admission
- Unable to provide consent or consent unavailable
- Unable to provide a pain score
- Pregnancy
- Prisoners
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
UC Davis Health
Sacramento, California, United States, 95817
Actively Recruiting
Research Team
C
Christine S Cocanour, MD
CONTACT
G
G J Jurkovich, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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