Clinical efficacy of magnesium sulfate injection in the treatment of masseter muscle trigger points: a randomized clinical study.
Shaimaa Mohsen Refahee, Aliaa Ibrahim Mahrous, Alshaimaa Ahmed Shabaan
https://pubmed.ncbi.nlm.nih.gov/36123724/Actively Recruiting
Led by Cairo University · Updated on 2026-02-05
28
Participants Needed
1
Research Sites
N/A
Total Duration
This clinical trial investigates the treatment of Myofascial Pain Dysfunction Syndrome MPDS, a condition involving painful muscle trigger points. Researchers aim to compare the effects of two types of trigger point injections lidocaine alone versus lidocaine combined with magnesium sulfate. The goal is to determine if adding magnesium sulfate improves pain relief and muscle relaxation in patients with MPDS. Participants will be randomly assigned to one of two groups. One group will receive injections of 2% preservative-free lidocaine alone, while the other group will receive injections combining 2% lidocaine with 10% magnesium sulfate. The injections will be given into the most painful trigger points using a specific technique called Fast-in, fast out or peppering. The study will assess pain levels using the Visual Analog Scale VAS and muscle activity through surface electromyography sEMG at baseline, 1 week, and 2 weeks after injection. Throughout the study, participants will be evaluated for pain reduction and muscle function improvement at multiple time points. Pain during and after injections will also be measured. The study involves visits for injections and follow-up assessments to monitor changes in pain and muscle activity. This research may help improve treatment strategies for MPDS by providing evidence on the use of magnesium sulfate as an add-on to lidocaine injections.
CONDITIONS
Magnesium Sulfate as an Adjuvant to Lidocaine in MPDS Trigger Point Injections Assessed by VAS and sEMG.
M
Maii E Abdelazeem, BSc
K
Khaled A Elhayes, PhD
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Cairo University
Lead Sponsor
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Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Single injection with assessments up to 2 weeks
Participants receive trigger point injections of lidocaine alone or lidocaine combined with magnesium sulfate to relieve pain and improve muscle relaxation.
1 injection visit and 2 follow-up visits at 1 week and 2 weeks post-injection
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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Shaimaa Mohsen Refahee, Aliaa Ibrahim Mahrous, Alshaimaa Ahmed Shabaan
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https://pubmed.ncbi.nlm.nih.gov/35339694/Cairo University
Lead Sponsor