Intravenous Magnesium Sulfate to Reduce Opioid Use and Manage Pain During Laparoscopic Appendectomy in Children

What this Trial Is About

Researchers are evaluating how intravenous magnesium sulfate infusion affects opioid use and the bodys circulatory, metabolic, and hormonal responses during anesthesia for laparoscopic appendectomy in children. Magnesium has antinociceptive and anti-inflammatory effects and is commonly used as a co-analgesic in adults. However, its effectiveness in children lacks strong scientific evidence, and this study aims to provide high-quality data on its use in pediatric surgery. The study compares two groups one receiving magnesium sulfate as an intravenous bolus before anesthesia induction followed by continuous infusion during surgery, and the other receiving a placebo of normal saline in the same manner. The magnesium dose is 50 mgkg as a bolus and 15 mgkghour during the operation. The infusion stops before the patient is moved to the postanesthesia care unit. Participants will be monitored from tracheal intubation through postanesthesia care unit admission, with measurements including opioid consumption, heart rate and blood pressure changes, metabolic and hormonal markers glucose, cortisol, IL-6, magnesium blood levels, and any side effects such as low blood pressure or allergic reactions. The primary outcome is the number of patients needing rescue opioid doses. Secondary outcomes include detailed intraoperative opioid use and physiological responses. The study will last until October 2027.

Magnesium Sulfate in Children Undergoing Laparoscopic Appendectomy