Actively Recruiting
Magnesium Sulfate in Children Undergoing Laparoscopic Appendectomy
Led by Medical University of Warsaw · Updated on 2024-11-12
188
Participants Needed
1
Research Sites
159 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Magnesium sulfate is one of the most commonly used co-analgetics. Its antinociceptive effect is related to antagonizing NMDA (N-methyl-D-aspartate) receptors of the nervous system, has an anti-inflammatory effect by reducing the concentration of IL-6 (interleukin 6) and tumor necrosis factor alpha. In adult patients, the need for morphine in the perioperative period is reduced when magnesium infusion is used. In current guidelines for treatment of acute pain in children, magnesium sulfate may be considered as a co-analgetic. However, the strength of such a recommendation is low due to the lack of reliable scientific research confirming the effectiveness of magnesium infusion in the pediatric population. The aim of this study is to evaluate the efficacy of intravenous magnesium sulfate infusion on the opioid consumption, the circulatory, metabolic and hormonal response to intubation and surgical trauma during anesthesia for laparoscopic appendectomy in children.
CONDITIONS
Official Title
Magnesium Sulfate in Children Undergoing Laparoscopic Appendectomy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- ASA physical status class 1E, 2E, or 3E (emergency)
- Undergoing laparoscopic appendectomy
You will not qualify if you...
- Allergy to magnesium sulfate or excipients
- Hypermagnesemia
- Renal failure with GFR less than 30 ml/min
- Myasthenia gravis
- Preoperative atrioventricular block
- Hypotension
- Use of digitalis glycosides
- Use of oral anticoagulants
- ASA physical status class 4E or higher
- Chronic treatment with analgesics
- Refusal by patient or legal guardian
AI-Screening
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Trial Site Locations
Total: 1 location
1
Uniwersity Clinic Centre of Medical Uniwersity of Warsaw
Warsaw, Poland, 02-091
Actively Recruiting
Research Team
A
Alicja Kuczerowska, MD
CONTACT
M
Maciej Kaszyński, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
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