Actively Recruiting
Magnetic Brain Stimulation and Computer-based Motor Training for Rehabilitation After Stroke
Led by Max Planck Institute for Human Cognitive and Brain Sciences · Updated on 2023-11-09
24
Participants Needed
1
Research Sites
201 weeks
Total Duration
On this page
Sponsors
M
Max Planck Institute for Human Cognitive and Brain Sciences
Lead Sponsor
U
University of Halle Medical Faculty
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of the present clinical trial is to explore whether an innovative technology-based approach can help individuals who have had a stroke and can no longer move their hands with ease. Our approach consists of a combination of two technologies: Transcranial Magnetic Stimulation (TMS) and a Brain-Computer Interface (BCI). The former entails the application of magnetic fields over the head to stimulate the brain preparing it for a better ability to produce movement. The latter consists of measuring brain activity to personalize a type of computer-based training that is designed to increase communication between the brain and the muscles.
CONDITIONS
Official Title
Magnetic Brain Stimulation and Computer-based Motor Training for Rehabilitation After Stroke
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of a subcortical stroke at least 6 months before the trial confirmed by MRI or CT
- Moderate to severe hemiparesis in an upper limb
- Sufficient language comprehension and visual and auditory perception to engage in Brain Computer Interface training
- Age between 20 and 80 years old
- Clear consciousness and stable vital signs
- Eligible for MRI, EEG, BCI, and TMS procedures
You will not qualify if you...
- Current or recent drug abuse or medication changes affecting the central nervous system (e.g., benzodiazepines, serotoninergic and dopaminergic agents)
- History of seizures
- Bone, joint, or muscle diseases
- Peripheral neuropathy or other neurological or psychiatric conditions (including tinnitus, migraine, mood disorders except mild to moderate depression with Beck depression scale score below 29)
- Severe cognitive deficits with Montreal Cognitive Assessment score 24 or below
- Lesions in the upper extremities
- Severe spasticity (greater than 3) or pain affecting wrist extension
- Contraindications for TMS (history of seizures, epilepsy, unclear unconsciousness, migraines, metals in the head)
- Contraindications for MRI (metals in the body, metallic prosthetics, claustrophobia)
- Participation in BCI or rTMS interventional trials within the last 6 months
- Participation in any other interventional clinical trial
- Suspected inability to comply with study procedures
- Pregnancy or nursing
AI-Screening
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Trial Site Locations
Total: 1 location
1
Max Planck Institute for Human Cognitive and Brain Sciences
Leipzig, Saxony, Germany, 04103
Actively Recruiting
Research Team
A
Aimee Arely Flores Sandoval, MsC
CONTACT
A
Arno Villringer, MD PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
TREATMENT
Number of Arms
2
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