Study of Heart Metabolism Using Magnetic Resonance Spectroscopy in Normal and Heart Disease Patients

What this Trial Is About

Researchers are studying the metabolism of the heart to understand how it produces the energy needed for normal heart contractions. This study uses magnetic resonance spectroscopy, a special MRI technique, to directly measure heart metabolism without the need for blood tests or biopsies. The study aims to explore whether reduced energy metabolism contributes to poor heart function in conditions like heart failure. The study involves measuring heart metabolism and function in healthy individuals and patients with conditions such as left ventricular hypertrophy, dilated cardiomyopathy, and coronary artery disease. Magnetic resonance spectroscopy is performed during rest and stress to assess various metabolic markers in these groups. Participants will undergo magnetic resonance spectroscopy scans to evaluate energy metabolism markers like phosphocreatineadenosine triphosphate ratio and creatine kinase flux. The study also collects data on other metabolites and sodium distribution in the heart. Researchers monitor these measures to better understand heart metabolism differences across conditions. The study began in 1988 and plans to continue through August 2028, including healthy volunteers aged 18 and older.

Magnetic Resonance Spectroscopy Studies of Cardiac Muscle Metabolism