Actively Recruiting
Magnetic Seizure Therapy in Bipolar Depression (MST-BpD) and Treatment Resistant Depression (MST-TRD)
Led by Joao L. DeQuevedo · Updated on 2025-12-03
60
Participants Needed
1
Research Sites
174 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to compare the efficacy and side effects magnetic seizure therapy (MST) and electroconvulsive therapy (ECT) in Bipolar Depression (MST-BpD) and Treatment Resistant Depression (MST-TRD).
CONDITIONS
Official Title
Magnetic Seizure Therapy in Bipolar Depression (MST-BpD) and Treatment Resistant Depression (MST-TRD)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosed with Bipolar I or II current depressive episode or treatment resistant depression requiring rapid response
- Adults aged 22 to 85 years
- Both males and females of any race and ethnic group
- Ability to provide informed consent or assent
- Ability to follow study procedures
- Females of reproductive potential must use highly effective contraception for at least 1 month prior and during study, and for 1 week after treatment
- Males of reproductive potential must use effective contraception
- Sufficient English to complete self-rated scales
- Good general health confirmed by medical clearance
- Stable psychotropic medication regimen for at least 6 weeks prior to study entry
You will not qualify if you...
- Implanted devices activated or controlled by physiological signals (e.g., pacemakers, defibrillators, nerve stimulators, implanted medication pumps)
- Conductive, ferromagnetic, or magnetic-sensitive metal implants near head or treatment coil
- Vascular, traumatic, infectious, or metabolic brain lesions
- Sleep deprivation or alcoholism
- Current or unstable substance use disorder except nicotine or caffeine, stable remission defined as at least 6 months
- Pregnant or nursing
- History of epilepsy or unexplained seizures
- History of space-occupying intracranial pathology
- Diseases likely to cause hemorrhage (e.g., subdural hematoma, aortic aneurysm)
- Degenerative central nervous system diseases like dementia
- Anesthesia contraindications including significant cardiac or medical risks
- Body mass index over 60
- Severe personality disorder interfering with follow-up
- Imminent suicide risk
- Inability to comply with study requirements
- Terminal illness with expected survival under 12 months
- Bipolar depression with psychotic features
- Allergic reactions to anesthetic or induction agents
- Participation in other clinical trials within 30 days
- Use of disallowed medications including antiepileptics and benzodiazepines (with some exceptions) or lithium before procedure
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
The University of Texas Health Science Center at Houston
Houston, Texas, United States, 77030
Actively Recruiting
Research Team
J
Joao L. De Quevedo, MD, PhD
CONTACT
A
Ana Ruiz
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here