Actively Recruiting
MAGNIFY - Pulmonary Magnetic Resonance Imaging for Cystic Fibrosis
Led by Sheffield Teaching Hospitals NHS Foundation Trust · Updated on 2026-04-29
60
Participants Needed
1
Research Sites
279 weeks
Total Duration
On this page
Sponsors
S
Sheffield Teaching Hospitals NHS Foundation Trust
Lead Sponsor
U
University of Sheffield
Collaborating Sponsor
AI-Summary
What this Trial Is About
This research study is looking at new ways of measuring the function of the lungs in patients with cystic fibrosis. This study is using the most advanced methods for measuring lung function including 2 tests called hyperpolarised gas magnetic resonance imaging (HP MRI) and multiple breath washout (MBW), to better understand changes in the lungs over time. HP MRI involves taking pictures of the air in your lungs after breathing in a harmless gas (xenon). MBW is a breathing test used to calculate something called the lung clearance index (LCI). By measuring these tests on the same day, alongside standard lung function tests, we aim to understand lung function in greater detail than ever before.
CONDITIONS
Official Title
MAGNIFY - Pulmonary Magnetic Resonance Imaging for Cystic Fibrosis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Confirmed clinical diagnosis of cystic fibrosis with 2 disease-causing CFTR mutations and positive sweat chloride (>60 mmol/L) or clinical confirmation by a senior CF physician
- Able to attend the Royal Hallamshire Hospital in Sheffield for scans
- For 129Xe-MRI and lung function cohorts (1, 2, and 3): aged 5 years or older
- For cohort 1: FEV1 greater than 30% predicted (best in previous 6 months)
- Previous participation in the MMAVIC study with at least one prior lung ventilation MRI measurement (for cohort 1)
- For cohort 4 (1H MRI only): aged between 1 and 5 years
You will not qualify if you...
- Previous lung transplant
- Infection with Burkholderia cepacia complex, MRSA, or Mycobacterium abscessus
- Pregnancy (except participants who become pregnant after consent; no research visits during pregnancy)
- Resting oxygen saturation (SpO2) below 90% in room air
- Unable to lie comfortably on their back for more than 60 minutes
- Any contraindications to MRI scanning as per hospital MRI questionnaire
- Pulmonary exacerbation within 4 weeks before research visit (no new treatments or symptom changes during that time)
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
University of Sheffield MRI Unit
Sheffield, United Kingdom
Actively Recruiting
Research Team
J
Jim Wild, Professor
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
5
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