Actively Recruiting
MAGNITUDE: A Phase 3 Study of NTLA-2001 in Participants With Transthyretin Amyloidosis With Cardiomyopathy (ATTR-CM)
Led by Intellia Therapeutics · Updated on 2026-03-27
1200
Participants Needed
132
Research Sites
224 weeks
Total Duration
On this page
Sponsors
I
Intellia Therapeutics
Lead Sponsor
R
Regeneron Pharmaceuticals
Collaborating Sponsor
AI-Summary
What this Trial Is About
To evaluate the efficacy and safety of a single dose of NTLA-2001 compared to placebo in participants with ATTR-CM.
CONDITIONS
Official Title
MAGNITUDE: A Phase 3 Study of NTLA-2001 in Participants With Transthyretin Amyloidosis With Cardiomyopathy (ATTR-CM)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Documented diagnosis of ATTR amyloidosis with cardiomyopathy
- Medical history of heart failure
- Heart failure symptoms are optimally managed and clinically stable within 28 days before study treatment
- Screening NT-proBNP blood level between 600 and 10,000 pg/mL
You will not qualify if you...
- New York Heart Association Class IV heart failure
- Polyneuropathy Disability score of IV (confined to wheelchair or bed)
- Infection with hepatitis B, hepatitis C, or HIV
- Active malignancy within 3 years before screening
- RNA silencer therapy within 12 months before dosing, including patisiran, inotersen, eplontersen; any prior use of vutrisiran is not allowed
- Starting tafamidis or acoramidis within 56 days before dosing
- Estimated glomerular filtration rate less than 30 mL/min/1.73m^2
- History of liver disease
- Uncontrolled blood pressure
- Unable or unwilling to take vitamin A supplements during the study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 132 locations
1
University of Arizona
Tucson, Arizona, United States, 85724
Actively Recruiting
2
Cedars-Sinai Medical Center
Los Angeles, California, United States, 90048
Actively Recruiting
3
Western Greater Los Angeles VA Medical Center
Los Angeles, California, United States, 90073
Actively Recruiting
4
Stanford University
Palo Alto, California, United States, 94305
Actively Recruiting
5
University of California, San Diego (UCSD) - Medical Center
San Diego, California, United States, 92103
Actively Recruiting
6
University of Colorado Denver
Denver, Colorado, United States, 80045
Actively Recruiting
7
Yale University School of Medicine
New Haven, Connecticut, United States, 06510
Actively Recruiting
8
MedStar Washington Hospital Center - MedStar Heart and Vascular Institute
Washington D.C., District of Columbia, United States, 20010
Actively Recruiting
9
Mayo Clinic - Jacksonville
Jacksonville, Florida, United States, 32224
Actively Recruiting
10
Cleveland Clinic of Florida
Weston, Florida, United States, 33331
Actively Recruiting
11
Emory University School of Medicine
Atlanta, Georgia, United States, 30322
Actively Recruiting
12
Northwestern University
Chicago, Illinois, United States, 60611
Actively Recruiting
13
Indiana University Health
Indianapolis, Indiana, United States, 46202
Actively Recruiting
14
University of Kentucky Gill Heart Institute
Lexington, Kentucky, United States, 40536
Actively Recruiting
15
Johns Hopkins University
Baltimore, Maryland, United States, 21287
Actively Recruiting
16
Brigham and Women's Hospital
Boston, Massachusetts, United States, 02115
Actively Recruiting
17
Boston University School of Medicine
Boston, Massachusetts, United States, 02118
Actively Recruiting
18
University of Michigan
Ann Arbor, Michigan, United States, 48109
Actively Recruiting
19
Barbara Ann Karmanos Cancer Institute
Detroit, Michigan, United States, 48201
Withdrawn
20
Mayo Clinic
Rochester, Minnesota, United States, 55905
Actively Recruiting
21
St. Luke's Hospital
Kansas City, Missouri, United States, 64111
Actively Recruiting
22
New York University (NYU) School of Medicine - Langone Medical Center
New York, New York, United States, 10016
Actively Recruiting
23
Columbia University Medical Center
New York, New York, United States, 10032
Actively Recruiting
24
Duke University Medical Center
Durham, North Carolina, United States, 27710
Actively Recruiting
25
Cleveland Clinic
Cleveland, Ohio, United States, 44195
Actively Recruiting
26
Ohio Health Research Institute
Columbus, Ohio, United States, 43214
Actively Recruiting
27
Oregon Health and Science University (OHSU)
Portland, Oregon, United States, 97239
Actively Recruiting
28
Penn Presbyterian Medical Center
Philadelphia, Pennsylvania, United States, 19104
Actively Recruiting
29
Allegheny General Hospital
Pittsburgh, Pennsylvania, United States, 15212
Actively Recruiting
30
University of Pittsburgh Medical Center
Pittsburgh, Pennsylvania, United States, 15219
Actively Recruiting
31
Medical University of South Carolina
Charleston, South Carolina, United States, 29425
Actively Recruiting
32
Baylor Scott & White Research Institute
Dallas, Texas, United States, 75201
Actively Recruiting
33
University of Texas Southwestern Medical Center
Dallas, Texas, United States, 75390
Actively Recruiting
34
Baylor College of Medicine
Houston, Texas, United States, 77030
Actively Recruiting
35
Houston Methodist Hospital
Houston, Texas, United States, 77030
Actively Recruiting
36
Baylor Scott and White - The Heart Hospital Baylor Plano
Plano, Texas, United States, 75093
Actively Recruiting
37
INOVA Fairfax Hospital
Falls Church, Virginia, United States, 22042
Actively Recruiting
38
Virginia Commonwealth University - Department of Internal Medicine
Richmond, Virginia, United States, 23298
Actively Recruiting
39
Fundacion Favalro
Buenos Aires, Argentina
Actively Recruiting
40
Hospital Italiano de Buenos Aires
Buenos Aires, Argentina
Actively Recruiting
41
ICBA
Buenos Aires, Argentina
Actively Recruiting
42
Fundacion Favaloro
Ciudad Autonoma de Buenos Aire, Argentina
Actively Recruiting
43
Hospital Italiano de Buenos Aires
Ciudad Autonoma de Buenos Aire, Argentina
Actively Recruiting
44
Hospital Privado de Rosario
Rosario, Argentina
Actively Recruiting
45
The Canberra Hospital
Garran, Australian Capital Territory, Australia
Actively Recruiting
46
Westmead Hospital
Westmead, New South Wales, Australia
Actively Recruiting
47
Cairns Hospital
Cairns, Queensland, Australia
Withdrawn
48
Eastern Health - Box Hill Hospital
Box Hill, Victoria, Australia
Actively Recruiting
49
Fiona Stanley Hospital
Perth, Western Australia, Australia
Actively Recruiting
50
Royal Adelaide Hospital
Adelaide, Australia
Actively Recruiting
51
The Alfred Hospital
Melbourne, Australia
Actively Recruiting
52
Princess Alexandra Hospital
Woolloongabba, Australia
Actively Recruiting
53
Medizinische Universitaet Innsbruck
Innsbruck, Austria
Actively Recruiting
54
Universitaesklinikum St. Poelten
Sankt Pölten, Austria
Actively Recruiting
55
AZ Sint-Jan Brugge
Bruges, Belgium
Actively Recruiting
56
Universite Libre de Bruxelles (ULB) - Hopital Erasme
Brussels, Belgium
Actively Recruiting
57
Antwerp University Hospital
Edegem, Belgium
Actively Recruiting
58
UZ Leuven
Leuven, Belgium
Actively Recruiting
59
Centre Hospitalier Regional de la Citadelle
Liège, Belgium
Actively Recruiting
60
Centro de Pesquisa NUPEC - Instituto Orizonti em Belo Horizonte
Belo Horizonte, Brazil
Actively Recruiting
61
Complexo Hospitalar de Niterói (CHN-DASA)
Niterói, Brazil
Actively Recruiting
62
CAPED - Centro Avancado de Pesquisa
Ribeirão Preto, Brazil
Actively Recruiting
63
HCFMRP - Hospital das Clinicas da Faculdade de Medicina de Ribeirao Preto
Ribeirão Preto, Brazil
Actively Recruiting
64
Cardiopulmonar da Bahia S. A. (Hospital Cardio Pulmonar)
Salvador, Brazil
Actively Recruiting
65
Hospital Israelita Albert Einstein
São Paulo, Brazil
Actively Recruiting
66
Instituto Dante Pazzanese de Cardiologia
São Paulo, Brazil
Actively Recruiting
67
Instituto do Coracao (InCor) do Hospital das Clinicas da FMUSP
São Paulo, Brazil
Actively Recruiting
68
PSEG Centro de Pesquisa Clinica S.A.
São Paulo, Brazil
Actively Recruiting
69
Alberta Health Services - University of Calgary
Calgary, Alberta, Canada
Actively Recruiting
70
Vancouver Coastal Health Research Institute
Vancouver, British Columbia, Canada
Actively Recruiting
71
University Health Network - Toronto General Hospital
Toronto, Ontario, Canada
Actively Recruiting
72
McGill University Health Centre
Montreal, Quebec, Canada
Actively Recruiting
73
Fakultni nemocnice u sv. Anny v Brne
Brno, Czechia
Actively Recruiting
74
Aarhus University Hospital
Aarhus, Denmark
Actively Recruiting
75
Rigshospitalet
Copenhagen, Denmark
Actively Recruiting
76
AP-HP Hopital Henri Mondor
Créteil, France
Actively Recruiting
77
AP-HM - Hopital de la Timone
Marseille, France
Actively Recruiting
78
AP-HP Hopital Bichat - Claude Bernard
Paris, France
Actively Recruiting
79
CHU Rennes - Hopital Pontchaillou
Rennes, France
Actively Recruiting
80
CHU de Toulouse - Hopital Rangueil
Toulouse, France
Actively Recruiting
81
Charite Universitaetsmedizin Berlin
Berlin, Germany
Actively Recruiting
82
Universitaetsklinikum Essen
Essen, Germany
Actively Recruiting
83
Universitaetsklinikum Heidelberg
Heidelberg, Germany
Actively Recruiting
84
Universitaetsklinikum Wuerzburg
Würzburg, Germany
Actively Recruiting
85
Semmelweis Egyetem Belgyogyaszati es Hematologiai Klinika
Budapest, Hungary
Actively Recruiting
86
Rambam Health Care Campus
Haifa, Israel
Actively Recruiting
87
Hadassah University Hospital, Ein Karem
Jerusalem, Israel
Actively Recruiting
88
Sheba Medical Center
Tel Litwinsky, Israel
Actively Recruiting
89
IRCCS Azienda Ospedaliero-Universitaria di Bologna - Policlinico di Sant'Orsola
Bologna, Italy
Actively Recruiting
90
Azienda Ospedaliero-Universitaria di Ferrara-Arcispedale Sant'Anna
Cona, Italy
Actively Recruiting
91
Azienda Ospedaliero-Universitaria Careggi
Florence, Italy
Actively Recruiting
92
Ospedale Policlinico San Martino IRCCS
Genova, Italy
Actively Recruiting
93
Fondazione IRCCS Policlinico San Matteo
Pavia, Italy
Actively Recruiting
94
Fondazione Toscana Gabriele Monasterio per la Ricerca Medica
Pisa, Italy
Actively Recruiting
95
Azienda sanitaria universitaria Giuliano Isontina (ASU GI) - Ospedale di Cattinara
Trieste, Italy
Actively Recruiting
96
Kumamoto University Hospital
Kumamoto, Japan
Actively Recruiting
97
National Cerebral and Cardiovascular Center
Osaka, Japan
Actively Recruiting
98
The University of Tokyo Hospital
Tokyo, Japan
Actively Recruiting
99
Toyama University Hospital
Toyama, Japan
Actively Recruiting
100
Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Mexico City, Mexico
Actively Recruiting
101
University Medical Center
Groningen, Netherlands
Actively Recruiting
102
Erasmus MC
Rotterdam, Netherlands
Actively Recruiting
103
Universitair Medisch Centrum Utrecht
Utrecht, Netherlands
Actively Recruiting
104
New Zealand Clinical Research
Auckland, New Zealand
Actively Recruiting
105
New Zealand Clinical Research
Christchurch, New Zealand
Actively Recruiting
106
Oslo University Hospital - Rikshospitalet
Oslo, Norway
Actively Recruiting
107
Centro Hospitalar Universitario de Lisboa Norte
Lisbon, Portugal
Actively Recruiting
108
Centro Hospitalar Universitario do Porto
Porto, Portugal
Actively Recruiting
109
National Heart Centre
Singapore, Singapore
Actively Recruiting
110
National University Hospital
Singapore, Singapore
Actively Recruiting
111
Chonnam National University Hospital
Gwangju, South Korea
Withdrawn
112
Samsung Medical Center
Seoul, South Korea
Withdrawn
113
Seoul National University Hospital
Seoul, South Korea
Withdrawn
114
Severance Hospital, Yonsei University Health System
Seoul, South Korea
Withdrawn
115
Hospital Universitario de A Coruna
A Coruña, Spain
Actively Recruiting
116
Hospital Universitari de Bellvitge
Barcelona, Spain
Actively Recruiting
117
Hospital Universitario Vall d'Hebron
Barcelona, Spain
Actively Recruiting
118
Hospital Universitario Puerta de Hierro
Majadahonda, Spain
Actively Recruiting
119
Hospital Universitario Virgen de la Victoria
Málaga, Spain
Actively Recruiting
120
Hospital Universitario Son Llatzer
Palma de Mallorca, Spain
Actively Recruiting
121
Karolinska University Hospital
Stockholm, Sweden
Actively Recruiting
122
University Hospital of Umea
Umeå, Sweden
Actively Recruiting
123
Far Eastern Memorial Hospital
New Taipei City, Taiwan
Actively Recruiting
124
National Taiwan University Hospital
Taipei, Taiwan
Actively Recruiting
125
Taipai Veterans General Hospital
Taipei, Taiwan
Actively Recruiting
126
Synexus Midlands Clinical Research Centre
Birmingham, United Kingdom
Active, Not Recruiting
127
Synexus Wales Clinical Research Centre
Cardiff, United Kingdom
Active, Not Recruiting
128
Synexus Scotland Clinical Research Centre
Glasgow, United Kingdom
Active, Not Recruiting
129
Synexus Hexham Clinical Research Centre
Hexham, United Kingdom
Active, Not Recruiting
130
Synexus Merseyside Clinical Research Centre
Liverpool, United Kingdom
Active, Not Recruiting
131
Richmond Pharmacology
London, United Kingdom
Actively Recruiting
132
Synexus Manchester Clinical Research Centre
Manchester, United Kingdom
Active, Not Recruiting
Research Team
T
Trial Manager at Intellia
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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