Actively Recruiting
Maintaining Immune and Mitochondrial Functions in Old Adults With SAfe Nutrition.
Led by Patrizia D'Amelio · Updated on 2025-05-31
240
Participants Needed
1
Research Sites
156 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Aging is associated with an increased inflammation named "inflammageing" and with an altered immune response. Different mechanisms have been proposed to explain the phenomenon of inflammageing and increased oxidative stress: deficiencies in essential amino acids, and some micronutrients have an important impact and may induce immune cell dysregulation. Mitochondrial dysfunction may explain the complex relationship between malnutrition sarcopenia, immune dysfunction and aging. Therefore, a personalized nutritional strategy aiming to improve mitochondrial function, decrease oxidative stress, down-regulate inflammation and restore immunity appears to be a logical approach in order to treat malnutrition and its biological and clinical consequences. MIMOSA will investigate the role of nutritional supplements in rescuing altered mitochondrial function and redox state imbalance.
CONDITIONS
Official Title
Maintaining Immune and Mitochondrial Functions in Old Adults With SAfe Nutrition.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 75 years or older
- Patients entering a rehabilitation program
- Diagnosis of malnutrition defined by a Mini Nutritional Assessment short form score below 11 points
- Willingness and ability to accept the nutritional supplement and provide written informed consent
- Ability to understand and comply with study requirements
You will not qualify if you...
- Presence of malignancy
- Life expectancy less than two months based on Multidimensional Prognostic Index
- Congestive heart failure classified as NYHA IV
- Chronic renal disease with creatinine clearance below 40 ml/min
- Liver cirrhosis classified as Child B or C
- Use of tube feeding, percutaneous endoscopic gastrostomy, or parenteral nutrition
- Severe difficulty swallowing (dysphagia)
- Mini-Mental State Examination score less than 18 or Mini Nutritional Assessment score above 11
- Severe anemia with hemoglobin below 10 g/l or leukopenia below 2 G/l
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
CHUV
Lausanne, Switzerland, Switzerland, 1012
Actively Recruiting
Research Team
P
Patrizia D'amelio
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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