Comparing Cementless and Cemented Mako Robotic-arm Assisted Total Knee Replacement Surgery in Adults

What this Trial Is About

Researchers are evaluating the outcomes of two types of total knee arthroplasty TKA in patients with symptomatic knee osteoarthritis. This prospective, randomized, single-blinded controlled trial compares functional, radiological, and clinical results of Mako robotic-arm assisted cementless TKA versus cemented TKA. The study aims to assess if cementless fixation offers superior benefits, considering the increasing number of younger patients undergoing TKA and concerns over implant loosening and patient satisfaction. Participants will receive Mako robotic-arm assisted total knee arthroplasty using either cementless or cemented implants. The robotic system uses preoperative CT scans to create a 3D model for precise bone resection and implant positioning. Patients are assigned to either the cementless or cemented TKA group, with surgery planned to optimize limb alignment and bone preservation. The trial is a superiority design aiming to determine if cementless TKA leads to better outcomes. During the study, participants will be followed for up to five years with various assessments including the Forgotten Joint Score at one year, radiostereometric analysis to measure implant migration, and clinical evaluations such as knee mobility, pain requirements, and quality of life questionnaires. Safety, complications, and healthcare costs will also be tracked. Follow-up visits will include radiographs and clinical reviews to monitor implant stability and function over time.

Mako Cementless TKA vs Mako Cemented TKA