Actively Recruiting
Malabsorption Blood Test (MBT) to Determine Exocrine Pancreatic Function and Related Quality of Life in Chronic Pancreatitis
Led by Anna Evans Phillips · Updated on 2026-04-27
80
Participants Needed
2
Research Sites
123 weeks
Total Duration
On this page
Sponsors
A
Anna Evans Phillips
Lead Sponsor
J
Johns Hopkins University
Collaborating Sponsor
AI-Summary
What this Trial Is About
This project uses the Malabsorption Blood Test (MBT) to identify patients with recurrent acute or chronic pancreatitis who have mild to moderate exocrine pancreatic insufficiency. A subgroup of patients who have response to pancreatic enzyme replacement therapy will enter a randomized, placebo-controlled pilot clinical trial for 8 weeks to identify improvements in quality of life (QOL).
CONDITIONS
Official Title
Malabsorption Blood Test (MBT) to Determine Exocrine Pancreatic Function and Related Quality of Life in Chronic Pancreatitis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Recurrent acute pancreatitis with at least 2 documented attacks meeting at least 2 of 3 acute pancreatitis criteria OR chronic pancreatitis meeting Cambridge I or II with history of acute pancreatitis OR Cambridge III or IV criteria
- Fecal elastase level of 50 or higher within the past 12 months
You will not qualify if you...
- Allergy or intolerance to pancreatic enzyme replacement therapy or Malabsorption Blood Test
- Taking medications that affect fat absorption or fatty acid supplements such as orlistat, ursodeoxycholic acid, or Fatty-15
- Use of GLP-1 receptor agonist therapy
- Fecal elastase level less than 50 within past 12 months or diagnosis of severe exocrine pancreatic insufficiency or ongoing fatty diarrhea
- Use of pancreatic enzyme replacement therapy for more than 5 days in the past 30 days
- Acute pancreatitis attack within the past 90 days
- History of pancreatic surgery or malabsorptive disease
- Pregnant or breastfeeding
- Other significant medical conditions as determined by the principal investigator
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Johns Hopkins Medicine
Baltimore, Maryland, United States, 21287
Not Yet Recruiting
2
University of Pittsburgh Medical Center
Pittsburgh, Pennsylvania, United States, 15213
Actively Recruiting
Research Team
A
Anna E Phillips, MD MS
CONTACT
A
Apsara Mishra, BSC
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
SEQUENTIAL
Primary Purpose
TREATMENT
Number of Arms
6
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