Actively Recruiting
Male Fertility Preservation Using Cryopreservation of Testicular Tissue Before Highly Gonadotoxic Cancer Treatment
Led by Gumy-Pause Fabienne · Updated on 2026-05-27
100
Participants Needed
3
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying fertility preservation in male children and adolescents with cancer who are undergoing treatments that may harm their reproductive functions. The study focuses on cryopreserving testicular tissue in prepubertal boys and in pubertal patients who have failed sperm cryopreservation. This research aims to improve options for preserving fertility in patients receiving highly gonadotoxic cancer therapies. It is a multicenter study sponsored by Gumy-Pause Fabienne. The intervention involves performing a testicular tissue biopsy under general anesthesia to collect tissue for cryopreservation. This procedure is experimental and offered to prepubertal patients aged 3 months and older who face a high risk of infertility due to cancer treatments such as high doses of alkylating agents or radiation. Pubertal patients who could not preserve sperm may also undergo this tissue cryopreservation. The study also creates a database and biobank for ongoing clinical and biological follow-up and future research. Participants will undergo the biopsy procedure before starting their cancer treatment. Researchers will monitor the number of patients undergoing tissue cryopreservation and assess any complications related to the biopsy. Biochemical markers will be compared during follow-up. The study involves collecting and recording clinical data and biological samples for long-term research. Participation may last through the treatment period and follow-up phases, with careful safety monitoring throughout.
CONDITIONS
Brief Title
Male Fertility Preservation Using Cryopreservation of Testicular Tissue Before Highly Gonadotoxic Cancer Treatment
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Prepubertal patients aged 3 months and older
- Peri and pubertal patients after failure of sperm cryopreservation
- Patients at high risk of infertility due to gonadotoxic treatments such as high doses of alkylating agents or irradiation
- Multidisciplinary team consensus supporting testicular tissue cryopreservation
You will not qualify if you...
- Patients under 3 months old
- Refusal of patient and/or parents
- Patients receiving treatments that are not highly gonadotoxic
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - 1 day
Participants undergo a testicular tissue biopsy during general anesthesia for fertility preservation before starting highly gonadotoxic cancer treatment.
1 visit (in-person)
Trial Site Locations
Total: 3 locations
1
UKBB
Basel, Switzerland
Actively Recruiting
2
Geneva University Hospitals
Geneva, Switzerland, 1211
Actively Recruiting
3
CHUV
Lausanne, Switzerland
Actively Recruiting
Research Team
F
Fabienne Gumy-Pause, Dr
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
PREVENTION
Number of Arms
1
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