Actively Recruiting
Male Fertility Preservation Using Cryopreservation of Testicular Tissue Before Highly Gonadotoxic Cancer Treatment
Led by Gumy-Pause Fabienne · Updated on 2022-11-02
100
Participants Needed
3
Research Sites
4435 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Background: Due to the remarkable improvement in treatments these last decades, long term survival can be expected in more than 80% of childhood cancer patients. Unfortunately, cancer treatments can be harmful to the gonads and can affect reproductive and endocrine functions. While loss of fertility is a major concern for most patients, sperm cryopreservation should be offered to all pubertal male patients. For prepubertal boys, only the experimental option of testicular biopsy in order to cryopreserve testicular stem cells can be proposed. Primary aims \- To cryopreserve testicular tissue of prepubertal patient receiving highly gonadotoxic oncological treatment. Secondary aims * To cryopreserve testicular tissue after failure of sperm cryopreservation in pubertal patient with high risk of infertility * To create a database in order to record clinical and biological follow-up data * To create a research biobank for future research projects Multicentric study: HUG, CHUV, UKBB
CONDITIONS
Official Title
Male Fertility Preservation Using Cryopreservation of Testicular Tissue Before Highly Gonadotoxic Cancer Treatment
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Prepubertal patients aged 3 months and older
- Peri- and pubertal patients after failure of sperm cryopreservation
- Patients at high risk of infertility due to gonadotoxic treatments such as high doses of alkylating agents, testicular irradiation, or total body irradiation
- Multidisciplinary team agrees to propose testicular tissue cryopreservation
You will not qualify if you...
- Patients younger than 3 months
- Patient or parents refuse participation
- Treatments are not highly gonadotoxic
AI-Screening
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Trial Site Locations
Total: 3 locations
1
UKBB
Basel, Switzerland
Actively Recruiting
2
Geneva University Hospitals
Geneva, Switzerland, 1211
Actively Recruiting
3
CHUV
Lausanne, Switzerland
Actively Recruiting
Research Team
F
Fabienne Gumy-Pause, Dr
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
PREVENTION
Number of Arms
1
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