Preserving Fertility in Boys and Young Men with Childhood Cancer by Freezing Testicular Tissue Before High-Risk Cancer Treatments

What this Trial Is About

Researchers are studying fertility preservation in male children and adolescents with cancer who are undergoing treatments that may harm their reproductive functions. The study focuses on cryopreserving testicular tissue in prepubertal boys and in pubertal patients who have failed sperm cryopreservation. This research aims to improve options for preserving fertility in patients receiving highly gonadotoxic cancer therapies. It is a multicenter study sponsored by Gumy-Pause Fabienne. The intervention involves performing a testicular tissue biopsy under general anesthesia to collect tissue for cryopreservation. This procedure is experimental and offered to prepubertal patients aged 3 months and older who face a high risk of infertility due to cancer treatments such as high doses of alkylating agents or radiation. Pubertal patients who could not preserve sperm may also undergo this tissue cryopreservation. The study also creates a database and biobank for ongoing clinical and biological follow-up and future research. Participants will undergo the biopsy procedure before starting their cancer treatment. Researchers will monitor the number of patients undergoing tissue cryopreservation and assess any complications related to the biopsy. Biochemical markers will be compared during follow-up. The study involves collecting and recording clinical data and biological samples for long-term research. Participation may last through the treatment period and follow-up phases, with careful safety monitoring throughout.

Male Fertility Preservation Using Cryopreservation of Testicular Tissue Before Highly Gonadotoxic Cancer Treatment