Actively Recruiting
Management of Dyssynergic Defecation
Led by Mayo Clinic · Updated on 2025-11-10
200
Participants Needed
1
Research Sites
206 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this research is to better understand constipation and improve biofeedback treatments.
CONDITIONS
Official Title
Management of Dyssynergic Defecation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Men and women aged 18-80 years who can provide written informed consent and comply with study requirements
- Meet Rome III criteria for functional constipation and/or irritable bowel syndrome based on questionnaires
- Have objective evidence of dyssynergic defecation on anorectal testing
You will not qualify if you...
- Significant cardiovascular, respiratory, renal, hepatic, gastrointestinal, hematological, neurological, psychiatric, or other diseases that may affect safety or study objectives
- History of total, hemi-, or subtotal colectomy or abdominal surgery within 60 days before the study (segmental colon resection for diverticulitis allowed)
- Current anal fissure
- Significant structural abnormalities like rectocele larger than 4 cm, large enterocele, or full thickness rectal prolapse
- Current or past colon or rectal cancer, scleroderma, inflammatory bowel disease, congenital anorectal abnormalities, solitary rectal ulcer syndrome, rectal resection, or pelvic irradiation
- Pregnant or nursing women, prisoners, and institutionalized individuals
- Body mass index over 35 kg/m2
- Use of opioid analgesics or GLP-1 receptor agonists (must stop opioids at least 1 week before screening and stay off during study)
- Current use of anticholinergics (e.g., amitriptyline, hyoscyamine) above low dose tricyclic antidepressants
- Use of laxatives, linaclotide, lubiprostone, or prucalopride unless discontinued at least 3 days before screening and stayed off during study
- Any other factors increasing risk or affecting data integrity
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Mayo Clinic
Rochester, Minnesota, United States, 55905
Actively Recruiting
Research Team
K
Kelly J. Feuerhak, RN, CCRP
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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