Actively Recruiting
Management of Dysuria and Irritative Symptoms After HoLEP: a Prospective Study Evaluating the Efficacy of Alpha-Blocker Therapy
Led by Ankara Training and Research Hospital · Updated on 2025-03-24
82
Participants Needed
1
Research Sites
25 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating the use of alpha-blocker therapy to manage dysuria and other irritative urinary symptoms following Holmium Laser Enucleation of the Prostate (HoLEP) surgery for benign prostatic hyperplasia (BPH). Although HoLEP is a minimally invasive and effective treatment, many patients experience irritative symptoms during the first three months after surgery, which can affect quality of life and patient satisfaction. The study aims to clarify the role of alpha-blockers in improving these symptoms after HoLEP, as previous research has focused mostly on other surgical techniques like TURP. The study involves two groups: one will receive alpha-blockers, specifically Tamsulosin Hydrochloride, while the other will not receive this treatment and serve as a comparison group. Participants are randomly assigned to either group. The treatment period focuses on the early postoperative phase, particularly within one month after surgery, when irritative symptoms are commonly reported. Participants will be monitored for symptoms such as dysuria and urgency using a visual analog scale (VAS) scored out of 10 points, as well as the International Prostate Symptom Score (IPSS) one month after surgery. Researchers will assess symptom severity, quality of life, and patient satisfaction. The study will collect these outcome measures to evaluate how alpha-blocker therapy affects urinary symptoms during the early recovery period after HoLEP.
CONDITIONS
Brief Title
Management of Dysuria and Irritative Symptoms After HoLEP: a Prospective Study Evaluating the Efficacy of Alpha-Blocker Therapy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Men over 40 years old and under 85 years old
- Have undergone Holmium Laser Enucleation of the Prostate (HoLEP) surgery
You will not qualify if you...
- Diagnosis of prostate cancer
- Presence of bladder stones
- History of urethral stricture
- Detrusor underactivity diagnosed by urodynamics
- Previous prostate surgery
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 1 month
Participants receive either alpha blocker therapy or no medication to evaluate effects on dysuria and irritative symptoms after HoLEP surgery.
Visits as needed during the treatment period
Trial Site Locations
Total: 1 location
1
Ankara bilkent city hospital
Ankara, Turkey (Türkiye)
Actively Recruiting
Research Team
K
Kazım Ceviz
A
Ankara Bilkent City Hospital Oncology
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
PREVENTION
Number of Arms
2
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