Actively Recruiting
Management of Gastrointestinal Bleeding Under Direct Oral Anticoagulants
Led by University Hospital, Strasbourg, France · Updated on 2026-01-12
250
Participants Needed
1
Research Sites
69 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Gastrointestinal bleeding (GIB) is a common emergency in hepatology and gastroenterology, with an overall mortality rate ranging from 5% to 10% depending on the study. GIB is classified into two categories: upper GIB (80% of cases) and lower GIB (20% of cases). There are many risk factors for GIB, including anticoagulants. In cases of GD under anticoagulants, there are specific management recommendations. In particular, in cases of severe bleeding under direct oral anticoagulants (DOACs), it is recommended to stop treatment and correct coagulation parameters according to the severity of the bleeding and the associated thrombotic risk. Various treatments can be used for this purpose, including specific antidotes, fresh frozen plasma, and prothrombin complex concentrate (PCC). However, the role of PCC in this indication is uncertain, as is the efficacy and safety data for this drug, due to significant methodological limitations in the few studies conducted on the subject.
CONDITIONS
Official Title
Management of Gastrointestinal Bleeding Under Direct Oral Anticoagulants
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult patient (≥ 18 years)
- Male or female
- Patient admitted to the emergency department for gastrointestinal bleeding (hematemesis, melena, rectal bleeding, or hematochezia)
- Taking a direct oral anticoagulant (dabigatran, apixaban, or rivaroxaban)
You will not qualify if you...
- Subject who has expressed their objection to the reuse of their data for scientific research purposes.
- Subject under guardianship, curatorship, or legal protection.
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Service des Urgences Adultes - CHU de Strasbourg - France
Strasbourg, France, 67091
Actively Recruiting
Research Team
V
Valérie WILME, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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