Actively Recruiting
Management of Malignant Gastric Outlet Obstruction Between Surgery and Endoscopy
Led by IRCCS San Raffaele · Updated on 2026-01-15
250
Participants Needed
5
Research Sites
189 weeks
Total Duration
On this page
Sponsors
I
IRCCS San Raffaele
Lead Sponsor
E
European Pancreatic Club
Collaborating Sponsor
AI-Summary
What this Trial Is About
The aim of this observational study is to compare the outcomes of three different procedures performed for the management of malignant Gastric Outlet Obstruction due to Pancreatic Cancer. Patients who undergo: * Surgical gastroenterostomy * Endoscopic placement of a self-expanding metallic stent * EUS-guided gastroenterostomy in accordance with standard clinical practice, will be enrolled to evaluate potential differences between the procedures in terms of clinical success, eating experience, chemotherapy tolerance, and nutritional status during follow-up. Participants will be asked to complete a quality of life questionnaire at baseline and during follow-up; however, no additional procedures will be conducted as a result of participation in the study.
CONDITIONS
Official Title
Management of Malignant Gastric Outlet Obstruction Between Surgery and Endoscopy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Confirmed pancreatic cancer by cytology or histology
- Diagnosis of pancreatic cancer within the last 6 months and candidate for active treatment
- Gastric outlet obstruction caused by tumor invasion or compression confirmed by imaging or endoscopy
- Candidate for one of the following procedures: endoscopic stent placement, EUS-guided gastroenterostomy, or surgical gastroenterostomy
You will not qualify if you...
- Under 18 years of age
- Benign or unclear gastrointestinal stenosis
- Gastric outlet obstruction caused by cancers other than pancreatic cancer
- Candidates for upfront surgical resection or those who already had curative pancreatic surgery
- Prior treatment for malignant gastric outlet obstruction
- Receiving additional biliary drainage procedures that increase risk or affect quality-of-life assessment, except uneventful biliary drainage done at least one day (endoscopic) or one month (surgical) before treatment
- Having any type of percutaneous drainage like biliary or ascites drainage
- Unable or unwilling to provide informed consent
- Contraindications to active palliation of malignant gastric outlet obstruction or requiring only venting gastrostomy or nasogastric tube palliation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 5 locations
1
Hôpital la pitié salpêtrière, APHP
Paris, France
Not Yet Recruiting
2
IRCCS San Raffaele Scientific Institute
Milan, Italy, 20132
Actively Recruiting
3
ISMETT - University of Palermo
Palermo, Italy
Not Yet Recruiting
4
São João University Hospital
Porto, Portugal
Not Yet Recruiting
5
Acibadem Maslak Hospital
Istanbul, Turkey (Türkiye)
Not Yet Recruiting
Research Team
G
Giuseppe Vanella, MD
CONTACT
L
Laura Apadula
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here