Exploring Metformin Treatment for Chronic Achilles Tendon Pain Effect on Pain Relief and Tendon Healing in Adults Aged 18 to 50

What this Trial Is About

Researchers are studying the effects of oral metformin capsules on chronic Achilles tendon pain and tendon healing in non-diabetic adults with this condition. The trial aims to assess how metformin affects tendon pain and repair, compared to placebo, in a randomized and blinded setting involving 40 participants with Achilles tendinopathy. Participants are randomly assigned to one of two groups one group receives metformin capsules while the other receives placebo capsules, both combined with a home exercise program delivered through a secure online portal. The dosing schedule starts with one capsule daily in week one, increasing weekly up to four capsules daily from weeks 4 to 16. The study includes three visits screeningbaseline, week 4, and week 16. During each visit, participants undergo functional testing, answer questionnaires, and have ultrasound scans of the Achilles tendon to measure various outcomes. Researchers will track changes in tendon pain scores, tendon thickness, tendon structure, and physical function over the 16-week treatment period. The main outcome measure is the change in the VISA-A score, which assesses Achilles tendon symptoms and function.

Managing Chronic Tendon Pain by Metformin