Actively Recruiting
Mandibular Overdentures vs All-on-4 With PEEK
Led by Menoufia University · Updated on 2025-08-22
40
Participants Needed
1
Research Sites
12 weeks
Total Duration
On this page
Sponsors
M
Menoufia University
Lead Sponsor
M
Mansoura University
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study compares long-term peri-implant outcomes between two mandibular full-arch rehabilitation approaches-four-implant-retained overdentures and All-on-4 fixed prostheses-when both are fabricated with polyetheretherketone (PEEK) frameworks. While overdentures and All-on-4 prostheses are widely used, evidence on the clinical performance of PEEK frameworks in these modalities is scarce. By evaluating marginal bone loss and other peri-implant parameters, the research aims to clarify whether prosthetic design influences biological outcomes when using this high-performance polymer.
CONDITIONS
Official Title
Mandibular Overdentures vs All-on-4 With PEEK
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 60 years
- Completely edentulous mandible for at least 6 months before implant placement
- Treated with either a four-implant-retained mandibular overdenture with a PEEK framework or a mandibular All-on-4 fixed prosthesis with a PEEK framework
- All implants placed in the lateral incisor and first premolar regions
- Restorations made with CAD/CAM-milled PEEK frameworks and acrylic denture teeth
- Prosthesis delivered using a delayed loading protocol
- Minimum clinical and radiographic follow-up of 4 years
- Availability of standardized baseline and follow-up periapical radiographs for bone level assessment
- Treated by the same surgical and prosthodontic team
You will not qualify if you...
- History of uncontrolled systemic diseases affecting bone healing (e.g., uncontrolled diabetes, osteoporosis under bisphosphonate therapy)
- History of head and neck radiotherapy
- Active periodontal or peri-implant infection at implant placement
- Insufficient bone volume in the interforaminal region requiring more than minor augmentation
- Heavy smoking (>10 cigarettes/day) at treatment time
- Parafunctional habits like severe bruxism or clenching
- Use of medications affecting bone metabolism (e.g., high-dose corticosteroids, antiresorptive drugs)
- Pregnancy at implant placement
- Incomplete clinical or radiographic records
- Follow-up period less than 4 years
AI-Screening
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Trial Site Locations
Total: 1 location
1
Faculty of Dentistry
Shibīn al Kawm, Menoufia, Egypt
Actively Recruiting
Research Team
M
Mohammed A. El-Sawy, PhD
CONTACT
M
Mohammed T. Khater, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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