Actively Recruiting
Manganese-enhanced Magnetic Resonance Imaging in Takotsubo Cardiomyopathy
Led by University of Edinburgh · Updated on 2026-03-24
100
Participants Needed
1
Research Sites
156 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this research study is to further understand the physiological mechanisms involved in a heart condition called takotsubo cardiomyopathy, also known as broken heart syndrome. Furthermore, the investigators will be assessing the effects different cardiac medications have on these physiological mechanisms. This will be achieved by performing cardiac MRI scans using a special dye called manganese. Manganese uptake in the heart is altered in patients with takotsubo cardiomyopathy. The investigators will study the effects that different cardiac medications have on manganese uptake.
CONDITIONS
Official Title
Manganese-enhanced Magnetic Resonance Imaging in Takotsubo Cardiomyopathy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Males and females over 18 years of age
- Clinical presentation of takotsubo cardiomyopathy
- Ability to give formal consent
You will not qualify if you...
- Unable to tolerate or contraindication to magnetic resonance imaging
- Renal failure with estimated glomerular filtration rate less than 30 mL/min/1.73 m2
- Prior history of cardiomyopathy
- Current pregnancy
- Weight greater than 250 kg
- Severe asthma (for participants receiving Bisoprolol)
- Type 1 diabetes mellitus (for participants receiving Dapagliflozin)
- Significant hypotension
- Significant bradycardia (for participants receiving Bisoprolol)
- Currently prescribed Digoxin
- Unable to give formal consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Edinburgh
Edinburgh, United Kingdom
Actively Recruiting
Research Team
J
Jennifer Ramsay
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
OTHER
Number of Arms
6
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