Actively Recruiting

Phase Not Applicable
Age: 18Years - 65Years
MALE
Healthy Volunteers
NCT06816056

Manual Therapy in Hemophilic Arthropathy of the Ankle

Led by Investigación en Hemofilia y Fisioterapia · Updated on 2025-02-10

13

Participants Needed

1

Research Sites

24 weeks

Total Duration

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AI-Summary

What this Trial Is About

Introduction: Haemophilic ankle arthropathy manifests as functional (deficit in muscle strength, mobility and proprioception), intra-articular degenerative alterations and chronic pain. Manual therapy techniques are characterised by treating the soft tissues with the aim of modifying their density, relieving pain, reducing tissue sensitivity and improving the ranges of mobility. The objective is to evaluate the safety and effectiveness of a manual therapy protocol in patients with haemophilic ankle arthropathy. Methods: Randomised crossover clinical trial. 13 patients with haemophilic ankle arthropathy from different regions of Spain will be recruited and randomised into two study groups (experimental and control). Each session of the experimental group will last 50 minutes, with 1 physiotherapy session per week for a period of 3 weeks. Patients will be evaluated at the beginning of the study, after the intervention and after a follow-up period of 4 weeks. The treatment programme includes 10 techniques that must be administered bilaterally. The study variables are the frequency of ankle haemarthrosis, range of movement, pressure pain threshold, pain intensity, joint status, biomechanical analysis of gait and balance, functionality and kinesiophobia. Expected results: To evaluate the safety of manual therapy in patients with haemophilia. To observe changes in pain, mobility, joint condition, stability and functionality of the ankle, and kinesiophobia.

CONDITIONS

Official Title

Manual Therapy in Hemophilic Arthropathy of the Ankle

Who Can Participate

Age: 18Years - 65Years
MALE
Healthy Volunteers

Eligibility Criteria

Eligible

You may qualify if you...

  • Patients diagnosed with haemophilia A or B
  • Severe haemophilia phenotype (less than 1% factor VIII or IX)
  • Age over 18 years and up to 65 years
  • Medical diagnosis of ankle arthropathy confirmed by Hemophilia Joint Health Score
  • Receiving prophylactic or on-demand coagulation factor VIII or IX treatment
Not Eligible

You will not qualify if you...

  • Neurological or cognitive disorders preventing understanding of questionnaires and physical tests
  • Not signing the informed consent document

AI-Screening

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Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

Universidad Católica San Antonio

Murcia, Spain

Actively Recruiting

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Research Team

R

Rubén Cuesta-Barriuso, PhD

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

DOUBLE

Allocation

RANDOMIZED

Model

CROSSOVER

Primary Purpose

TREATMENT

Number of Arms

2

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