Actively Recruiting
Mapping the Effect of (neuro)inflammation on Stress Sensitivity in the Brain of Healthy Men
Led by Universitaire Ziekenhuizen KU Leuven · Updated on 2024-10-01
20
Participants Needed
1
Research Sites
138 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this interventional study is to determine the effects of inflammation on stress responses in the brain of healthy men. In order to achieve this goal, participants are injected with an inflammation-inducing agent, then observed inside a brain scanner.
CONDITIONS
Official Title
Mapping the Effect of (neuro)inflammation on Stress Sensitivity in the Brain of Healthy Men
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male
- Healthy
- Age 18-45 years
- Body mass index (BMI) 18.5-25 kg/m2
- Proficient in English and/or Dutch
You will not qualify if you...
- Previous or current neuropsychiatric disorders or major head trauma
- Any disorder that might jeopardise safety or compliance
- Prior or current treatments that might jeopardise safety or study integrity
- Recent or prior medication use, especially antibiotics, cardiovascular drugs, steroids, non-steroid anti-inflammatory drugs, centrally effective drugs
- Participation in another interventional trial with investigational medicinal product or device
- Current or previous infection or vaccination within last 8 weeks
- Pathological blood values or genetic profiles affecting brain imaging
- Strong physical activity within 24 hours before the experiment
- Current smoker
- Night-shift worker
- Recent or previous use of psychotropic drugs within last year
- Regular high alcohol use (more than 4 drinks per week)
- Brain imaging contraindications including claustrophobia, severe back problems, cochlear implant, metal fragments in eyes, pacemaker, neural stimulator, or other metal implants
- Planning pregnancy during or within one month after study completion
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
UZ/KU Leuven
Leuven, Flemish Brabant, Belgium, 3000
Actively Recruiting
Research Team
L
Lukas Van Oudenhove, MD, PhD
CONTACT
D
Dina Satriawan, MD, Mnsci
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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