Actively Recruiting
Mapping Epileptic Networks Using Multimodal Imaging
Led by Imagine Institute · Updated on 2025-04-17
75
Participants Needed
1
Research Sites
834 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Currently, mapping the epileptogenic zone is based on a comprehensive preoperative assessment involving clinical, imaging and electrophysiological examinations. To reduce the need for invasive stereoelectroencephalography (SEEG) explorations, electrophysiological and imaging methods have been developed, such as resting-state functional MRI (fMRI) coupled with electroencephalogram and arterial spin-labeling perfusion MRI (ASL-MRI). It has been published that these new methods enable precise delineation of the epileptogenic zone and better preparation for surgery. The aim is to determine whether, in children with focal lesional epilepsy, the combination of ASL-MRI-EEG and resting-state fMRI-EEG enables precise identification of the epileptogenic zone to be defined by SEEG, the current reference examination.
CONDITIONS
Official Title
Mapping Epileptic Networks Using Multimodal Imaging
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Be under 18 years of age on the day of inclusion.
- Have refractory focal lesional epilepsy or rare non-lesional epilepsy.
- Show abnormalities (spikes) on the intercritical EEG.
- Be selected by the "Epilepsy" multidisciplinary staff.
- Require EEG-video recording with intracranial electrodes (SEEG) if having refractory lesional epilepsy.
- Be affiliated to a health insurance scheme.
You will not qualify if you...
- Require general anesthesia for MRI.
- Require sedation specifically for research purposes.
- Have generalized epilepsy.
- Be deprived of liberty or under guardianship.
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Necker - Enfants Malades Hospital
Paris, France, 75015
Actively Recruiting
Research Team
N
Nathalie Boddaert, Pr
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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