Actively Recruiting
Mapping of Human Cognition
Led by The University of Texas Health Science Center, Houston · Updated on 2025-08-28
75
Participants Needed
1
Research Sites
260 weeks
Total Duration
On this page
Sponsors
T
The University of Texas Health Science Center, Houston
Lead Sponsor
N
National Institute of Neurological Disorders and Stroke (NINDS)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this study is to compare organization of normal brain function as detected using Functional magnetic resonance imaging (fMRI) in normal subjects as opposed to patients with epilepsy or brain tumors, to ascribe precise anatomic labels (including Brodmann Areas) and functional significance to each region involved in cognitive processes as detected by cortical stimulation mapping (CSM) in patients with implanted subdural electrodes (SDE) or depth (sEEG) electrodes, to describe the locations of these regions in Talairach space, for a population of patients without overt structural abnormalities in these regions, to generate a spatial probability map of locations of cortical regions "essential" for these processes, to compare the loci of "crucial" language, visual, motor and cognitive sites as determined by CSM with the loci determined by a battery of tasks using fMRI for each individual and to use these data in patients undergoing intracranial electro-corticographyto determine the loci of essential, involved and uninvolved brain areas, and use sophisticated mathematical analyses of these intracranial recordings to study information flow between these areas.
CONDITIONS
Official Title
Mapping of Human Cognition
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with medically refractory epilepsy scheduled to undergo or who have undergone subdural or depth electrode placement to localize seizure onset and map critical language and motor regions
- Patients with epilepsy, brain tumors, or vascular malformations near crucial brain areas who are scheduled to undergo or have undergone intraoperative mapping or Wada test, or may be part of an awake craniotomy
- Proficiency in English
You will not qualify if you...
- Presence of large structural brain abnormalities that may affect critical brain areas
- Inability to participate due to impaired cognition or mental retardation
- Presence of cardiac pacemakers, intracranial aneurysm clips, or other mobile implanted metallic devices
- Claustrophobia preventing MRI without sedation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
The University of Texas Health Science Center at Houston
Houston, Texas, United States, 77479
Actively Recruiting
Research Team
N
Nitin Tandon, MD
CONTACT
E
Eliana M Klier
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
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