Actively Recruiting
Musculoskeletal Adaptive Platform Trial (MAPT): Fixation Versus Arthroplasty Surgical Treatments for Early Recovery After HIP Fracture (FASTER-HIP)
Led by University of Southern California · Updated on 2026-06-03
600
Participants Needed
13
Research Sites
48 weeks
Total Duration
On this page
Sponsors
U
University of Southern California
Lead Sponsor
P
Patient-Centered Outcomes Research Institute
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are evaluating surgical treatments for minimally displaced femoral neck fractures in adults aged 60 years and older. This pragmatic, randomized, open-label trial compares hip arthroplasty to internal fixation to see which approach better reduces death, preserves walking ability, increases days alive and out of the hospital, and improves health status within 4 and 12 months after surgery. The study is part of the Musculoskeletal Adaptive Platform Trial (MAPT), which tests multiple treatments under a common framework to find the best options for patients. Participants will be randomly assigned to one of two surgical treatments. One group will receive hip arthroplasty, where a modern porous-coated prosthesis is used by the surgeon to replace the hip joint. The other group will receive internal fixation, involving fixation devices like screws inserted through a small incision to stabilize the fracture. Surgeons have flexibility on specific implant types and surgical techniques within each treatment. The study compares these two approaches to assess their effectiveness and outcomes. During the study, participants will be monitored for death, ability to walk, and number of days alive and out of hospital at 120 days and 365 days after randomization. Additional assessments include quality of life measures and pain ratings during the first week after surgery. Patients will be followed closely to gather these outcomes and safety information. The trial aims to provide clear evidence on which surgical option offers better recovery and survival for older adults with this type of hip fracture.
CONDITIONS
Brief Title
MAPT Protocol: Fixation Versus Arthroplasty Surgical Treatments for Early Recovery After HIP Fracture (FASTER-HIP)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 60 years of age or older undergoing surgery due to a minimally displaced femoral neck fracture
- Health condition affecting physical mobility
- Complete femoral neck fracture confirmed by imaging
- Minimally displaced fracture suitable for arthroplasty or internal fixation without reduction
- Low energy injury mechanism
- Availability of surgeons skilled in internal fixation and hip arthroplasty
You will not qualify if you...
- Not clinically suitable for either surgical treatment
- Expected survival less than 12 months due to injury or terminal illness
- Incarceration
- Unable to provide informed consent due to language or lack of authorized representative
- Issues maintaining follow-up
- Currently enrolled in conflicting studies or prior enrollment in this domain
- Declined participation or missed screening
- Other exclusion reasons approved by data center
- Associated lower extremity injury preventing weight-bearing after surgery
- Retained hardware around the hip preventing study treatments
- Infection around the hip
- Pathologic fracture with lytic lesion precluding internal fixation
- Injury occurred more than 21 days before screening
- Judged too ill by surgeon for internal fixation or arthroplasty
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - During hospitalization, typically a few days
Participants undergo surgical treatment either with hip arthroplasty or internal fixation for their minimally displaced femoral neck fracture, followed by immediate post-operative care.
Daily assessments during initial hospitalization, including pain scoring for the first seven postoperative days
Duration - Up to 365 days after surgery
Participants are followed to assess recovery, ambulation status, health-related quality of life, and survival.
Follow-up visits at 120 days and 12 months post-randomization
Trial Site Locations
Total: 13 locations
1
University of California, Irvine
Irvine, California, United States, 92660
Actively Recruiting
2
Los Angeles General Medical Center
Los Angeles, California, United States, 90033
Actively Recruiting
3
University of Southern California
Los Angeles, California, United States, 90033
Actively Recruiting
4
Indiana University
Bloomington, Indiana, United States, 47405
Actively Recruiting
5
University of Maryland, Baltimore - R Adams Cowley Shock Trauma Center
Baltimore, Maryland, United States, 21201
Actively Recruiting
6
University of Maryland Capital Region Health
Largo, Maryland, United States, 20774
Actively Recruiting
7
University of Mississippi
University, Mississippi, United States, 38677
Actively Recruiting
8
University of Cincinnati
Cincinnati, Ohio, United States, 45221
Actively Recruiting
9
Vanderbilt University
Nashville, Tennessee, United States, 37235
Actively Recruiting
10
University of Utah
Salt Lake City, Utah, United States, 84108
Actively Recruiting
11
Inova Health Care Services
Fairfax, Virginia, United States, 22031
Actively Recruiting
12
University of British Columbia
Vancouver, British Columbia, Canada, V6T 1Z4
Actively Recruiting
13
Fraser Health Authority
Vancouver, British Columbia, Canada
Actively Recruiting
Research Team
J
Joseph Patterson, MD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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