Actively Recruiting
Marfan Syndrome Moderate Exercise Trial II
Led by Baylor College of Medicine · Updated on 2024-01-24
50
Participants Needed
1
Research Sites
199 weeks
Total Duration
On this page
Sponsors
B
Baylor College of Medicine
Lead Sponsor
S
Southern Star Research
Collaborating Sponsor
AI-Summary
What this Trial Is About
Marfan syndrome (MFS) is a distinctive connective tissue disorder that affects multiple organ systems including the heart, bones, ligaments, and eyes, and is associated with significant risk of aortic dissection. Given limited evidence from in-vitro studies, and theoretical concerns, the majority of patients with MFS are restricted from certain physical activities. The lack of exercise and deconditioning have detrimental effects including increasing weakness, joint pain, decreased endurance, and depressive symptoms. Given the significant paucity of data currently existing on the effects of exercise in humans with MFS, and the recent, optimistic findings in rodent models, this pilot trial was established to assess the effects of moderated dynamic exercise in adolescents and young adults with MFS.
CONDITIONS
Official Title
Marfan Syndrome Moderate Exercise Trial II
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male and female patients diagnosed with Marfan syndrome (defined by Ghent criteria and either a pathogenic variant in FBN1 or ectopia lentis)
- Age 10-25 years at enrollment
You will not qualify if you...
- History of aortic surgery
- History of spinal surgery with implanted materials that may affect MRI safety or quality
- Diagnosis of major congenital heart disease (other than ASD, VSD, bicuspid aortic valve, or mitral valve prolapse)
- Condition limiting the ability to perform moderate exercise
- Major concurrent diagnosis that may affect interpretation of study outcomes
- Aortic dilation 4.5 cm or larger requiring prophylactic surgery
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Texas Children's Hospital
Houston, Texas, United States, 77030
Actively Recruiting
Research Team
S
Shaine A Morris, MD, MPH
CONTACT
J
Jennifer Bogardus, PT, MPT, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here